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We assessed brain activation in response to food cues using <jats:sup>18<\/jats:sup>F\u20102\u2010fluoro\u20102\u2010deoxy\u2010glucose\u2010PET in 36 overweight women, stratified by low or high food addiction groups according to the Yale Food Addiction Scale (YFAS). Assessments were repeated after a 3\u2010month diet. We found greater activation in thalamus, hypothalamus, midbrain, putamen, and occipital cortex (reward), but not in prefrontal and orbitofrontal cortices (control\/reward receipt) in the high\u2010YFAS versus low\u2010YFAS group. In high\u2010YFAS subjects, orbitofrontal responsiveness was inversely related to YFAS severity and hunger rating, and positive associations were observed between regional brain activation and lipid intake. A 3\u2010month diet abolished group differences in brain activation. Our data suggest that food addiction distinguishes an overweight phenotype that can be reversed by diet, opening to personalized strategies in obesity treatment.<\/jats:p>","DOI":"10.1002\/erv.2652","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:23:28Z","timestamp":1540283008000},"page":"657-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Food addiction distinguishes an overweight phenotype that can be reversed by low calorie diet"],"prefix":"10.1002","volume":"26","author":[{"given":"Maria Angela","family":"Guzzardi","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-6145","authenticated-orcid":false,"given":"Silvia","family":"Garelli","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medical and Surgical Science, Centre for Applied Biomedical Research, S. 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