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They also investigated cortical surface parameters, for example, absolute mean curvature (AMC) providing information on cortical folding or sulcal depth (SD). For the first time, we also analysed cortical complexity using fractal dimension (FD) in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a cross\u2010sectional study, we performed surface analyses (AMC, SD, and FD) on 34 women with AN, 24 recovered from AN (REC), and 41 healthy controls (HC). Structural MR data was processed using the Computational Anatomy Toolbox and statistically compared across groups on a vertex\u2010 and region\u2010of\u2010interest\u2010wise level using statistical parametric mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a lower AMC and SD in AN, especially in temporal areas. FD was increased in the left precentral gyrus in AN. No differences of the parameters AMC, SD, or FD were evident between REC and HC participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alterations in AMC, SD, and FD in AN patients, but not between the REC and HC groups, suggest that these alterations are state related. The findings concur with other structural AN studies that suggest restitution with clinical recovery. The changes may be due to malnutrition, dehydration, osmotic dysregulation, or hormonal aberrations during the acute stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2685","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T05:39:10Z","timestamp":1559799550000},"page":"655-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Altered cortical folding and reduced sulcal depth in adults with anorexia nervosa"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-317X","authenticated-orcid":false,"given":"Kathrin","family":"Nickel","sequence":"first","affiliation":[{"name":"Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-4836","authenticated-orcid":false,"given":"Andreas","family":"Joos","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical Center \u2013 University of Freiburg Faculty of Medicine, University of Freiburg  Freiburg Germany"},{"name":"Psychotherapeutic Neurology Kliniken Schmieder  Gailingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Tebartz van Elst","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Holovics","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical Center \u2013 University of Freiburg Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Endres","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Zeeck","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical Center \u2013 University of Freiburg Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Maier","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical Center \u2013 University of Freiburg Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/5.1.56"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"559","article-title":"3D cerebral cortical morphometry in autism: Increased folding in children and adolescents in frontal, parietal, and temporal lobes","volume":"11","author":"Awate S. 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