{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:12Z","timestamp":1791888312848,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DNA methylation allows for the environmental regulation of gene expression and is believed to link environmental stressors to psychiatric disorder phenotypes, such as anorexia nervosa (AN). The oxytocin receptor (<jats:italic>OXTR<\/jats:italic>) gene is epigenetically regulated, and studies have shown associations between <jats:italic>OXTR<\/jats:italic> and social behaviours in various samples, including women with AN. The present study examined differential levels of methylation at various CG sites of the <jats:italic>OXTR<\/jats:italic> gene in 69 women with active AN (AN\u2010Active), 21 in whom AN was in remission (AN\u2010Rem) and 35 with no eating disorder (NED). Within each group, we explored the correlation between methylation and measures of social behaviour such as insecure attachment and social avoidance. Hypermethylation of a number of CG sites was seen in AN\u2010Active participants as compared with AN\u2010Rem and NED participants. In the AN\u2010Rem sample, methylation at CG27501759 was significantly positively correlated with insecure attachment (<jats:italic>r<\/jats:italic> = .614, <jats:italic>p<\/jats:italic> = .003, permutation <jats:italic>Q<\/jats:italic> = 0.008) and social avoidance (<jats:italic>r<\/jats:italic> = .588, <jats:italic>p<\/jats:italic> = .005, permutation <jats:italic>Q<\/jats:italic> = 0.0184). Our results highlight differential methylation of the <jats:italic>OXTR<\/jats:italic> gene among women with AN, those in remission from AN, and those who never had AN and provide some evidence of associations between <jats:italic>OXTR<\/jats:italic> methylation and social behaviour in women remitted from AN.<\/jats:p>","DOI":"10.1002\/erv.2703","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T07:44:55Z","timestamp":1576050295000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Methylation of the <i>OXTR<\/i> gene in women with anorexia nervosa: Relationship to social behavior"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-1240","authenticated-orcid":false,"given":"Lea","family":"Thaler","sequence":"first","affiliation":[{"name":"Eating Disorders Continuum, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"},{"name":"Psychiatry Department McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Brassard","sequence":"additional","affiliation":[{"name":"Eating Disorders Continuum, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Booij","sequence":"additional","affiliation":[{"name":"Psychology Department Concordia University  Montreal Quebec Canada"},{"name":"CHU Sainte\u2010Justine Hospital Research Centre University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kahan","sequence":"additional","affiliation":[{"name":"Eating Disorders Continuum, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Labbe","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Hospital Research Centre University of Montreal  Montreal Quebec Canada"},{"name":"Research Centre, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Israel","sequence":"additional","affiliation":[{"name":"Eating Disorders Continuum, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"},{"name":"Psychiatry Department McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Steiger","sequence":"additional","affiliation":[{"name":"Eating Disorders Continuum, Douglas Mental Health University Institute Montreal West Island Integrated University Health &amp; Social Service Centre (IUHSSC)  Montreal Quebec Canada"},{"name":"Psychiatry Department McGill University  Montreal Quebec Canada"},{"name":"Psychology Department McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10217"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22374"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.2.240"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00960784"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.95"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(198701)6:1<1::AID-EAT2260060102>3.0.CO;2-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0701-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579413000497"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-6-r43"},{"key":"e_1_2_8_11_1","first-page":"309","volume-title":"Cognitive behavior therapy and eating disorders","author":"Fairburn C. 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