{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:18:43Z","timestamp":1790705923818,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa (AN) is a serious mental illness with high rates of relapse and mortality. Psychiatric comorbidities are common but their impact on the prognosis is largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to investigate the influence of psychiatric comorbidity on weight gain during treatment of AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was performed in PubMed\/MEDLINE, EMBASE and PsycINFO. Studies evaluating psychiatric comorbidity as a predictor for treatment outcome (weight gain) were included, however, comorbid alcohol\/drug addiction was excluded from this review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four thousand five hundred and twenty six publications were identified from which 15 were included. The majority of the included studies had a prospective open naturalistic study design, a short\u2010term follow\u2010up period, and were based on small populations of primarily adolescent and adult women. Four studies indicate depression, and two obsessiveness as negative prognostic factors, whilst one study indicated moderate depression and yet another, neuroticism, as positive predictors for weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The systematic scoping review found a large number of publications whereof only a few directly described the influence of psychiatric comorbidity on weight gain in AN. Overall, studies were heterogeneous in design, purpose and outcome making comparisons difficult. Findings were divergent but depression had a negative influence on weight gain in four studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2787","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T17:01:20Z","timestamp":1599238880000},"page":"605-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Comorbid depression as a negative predictor of weight gain during treatment of anorexia nervosa: A systematic scoping review"],"prefix":"10.1002","volume":"28","author":[{"given":"Mia","family":"Eskild\u2010Jensen","sequence":"first","affiliation":[{"name":"Eating Disorder Unit Mental Health Center Ballerup Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-5544","authenticated-orcid":false,"given":"Ren\u00e9 K.","family":"St\u00f8ving","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders Odense University Hospital Odense Denmark"},{"name":"Endocrine Research Unit, Odense University Hospital &amp; Clinical Institute University of Southern Denmark Odense Denmark"},{"name":"Mental Health Services in the Region of Southern Denmark Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Flindt","sequence":"additional","affiliation":[{"name":"Eating Disorder Unit Mental Health Center Ballerup Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-1914","authenticated-orcid":false,"given":"Magnus","family":"Sjogren","sequence":"additional","affiliation":[{"name":"Eating Disorder Unit Mental Health Center Ballerup Ballerup Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000453"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22922"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.10.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000221254.77675.f5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-0963-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta7270"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170004335X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1972.01750190059011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22501"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10640266.2016.1241056"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000342"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22168"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-017-0405-x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90056-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20328"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20885"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0611-x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003185"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000050"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1123"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3658"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2416"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-014-0258-z"},{"key":"e_1_2_8_28_1","article-title":"Rate of weight gain as a predictor of readmission in adolescents with eating disorders","author":"Sebastian M. 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