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The aim of the present study is to investigate how enhanced cognitive flexibility is involved in treatment outcomes in patients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One hundred thirty female out\u2010patients treated for AN have been assessed at baseline and after 4 months of treatment. Path analyses were used to investigate the mediating role of cognitive flexibility, measured through the Brixton test, on a wide range of outcomes: body mass index, eating disorder symptoms, daily life functioning, anxiety, depression, emotions, self\u2010rated silhouette.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cognitive flexibility was improved during treatment, and enhanced cognitive flexibility explains a significant part of level of the improvement in\u00a0daily life functioning (26%), reduction of eating disorder symptoms (18%)\u00a0and reduction of depressive symptoms (17%). Others outcomes were also\u00a0improved, but these improvements were not mediated by cognitive flexibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest that enhancing cognitive flexibility could help reduce rigid cognitive and behavioural patterns involved in AN, thus improving everyday functioning and clinical severity. Further studies combining different types of cognitive flexibility evaluation as well as neuroimaging may be necessary to better establish which of its aspects are involved in patients' improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2829","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T22:39:05Z","timestamp":1618439945000},"page":"600-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Increased cognitive flexibility mediates the improvement of eating disorders symptoms, depressive symptoms and level of daily life functioning in patients with anorexia nervosa treated in specialised centres"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-6820","authenticated-orcid":false,"given":"Philibert","family":"Duriez","sequence":"first","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne, CMME  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-7753","authenticated-orcid":false,"given":"H\u00e9line","family":"Kaya Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne, CMME  Paris France"},{"name":"Universit\u00e9 de Paris LPPS  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Di Lodovico","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne, CMME  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Viltart","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 Universit\u00e9 de Paris  Paris France"},{"name":"Cit\u00e9 scientifique, SN4 Universit\u00e9 de Lille  Villeneuve d\u2019Ascq France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne, CMME  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-162"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Guideline for the treatment of patients with eating disorders (revision)","volume":"163","author":"American Psychiatric Association Workgroup on Eating Disorders Practice","year":"2006","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0734282907301592"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"15","article-title":"Three trail making tests for use in neuropsychological assessments with brief intertest intervals","volume":"32","author":"Atkinson T. 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