{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:18:00Z","timestamp":1790209080565,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Predictive values of acute phase metabolic abnormalities of anorexia nervosa (AN) have seldom been studied. As early postrestoration weight loss is associated with poor outcome, discharge biologic parameters were assessed to detect an association with 2\u2010month follow\u2010up weight loss as a proxy to poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fasting plasma levels of leptin, acyl\u2010ghrelin, obestatin, PYY, oxytocin and BDNF were measured in 26 inpatients, at inclusion, at discharge and 2 months later. A body mass index less than 18 2\u2010month postdischarge was considered a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients (73%) had a fair outcome and seven (27%) had a poor one with a mean loss of 0.69 versus 4.54\u00a0kg, respectively. Only discharge leptin levels were significantly higher in fair versus poor outcome patients (14.1 vs. 7.0\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). The logistic regression model using discharge leptin, acyl\u2010ghrelin, obestatin, oxytocin, PYY and BDNF levels as\u00a0predictors of outcome disclosed a nearly significant effect of leptin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.10). Receiver operating characteristic analysis showed 11.9\u00a0ng\/ml was the best value of threshold. Neither clinical variables differed according to outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leptin level may be a biomarker of early weight relapse after acute inpatient treatment of AN. Its clinical usefulness in monitoring care in AN should further be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2830","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:04:33Z","timestamp":1619053473000},"page":"634-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lower leptin level at discharge in acute anorexia nervosa is associated with early weight\u2010loss"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-178X","authenticated-orcid":false,"given":"Roland","family":"Dardennes","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Paris Descartes  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) Universit\u00e9 de Paris INSERM UMR\u2010S 1266  Paris France"},{"name":"Clinique des Maladies Mentales et de l'enc\u00e9phale Hospital Sainte\u2010Anne  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