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We examine the effects of probiotics supplementation on the gut MI in patients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a study protocol for a two\u2010centre double\u2010blind randomized\u2010controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment\u2010as\u2010usual compared to placebo in 60 patients with AN (13\u201319\u00a0years). Moreover, 60 sex\u2010 and age\u2010matched healthy controls are included in order to record development\u2010related changes. Assessments are conducted at baseline, discharge, 6 and 12\u00a0months after baseline. Assessments include measures of body mass index, psychopathology (including eating\u2010disorder\u2010related psychopathology, depression and anxiety), neuropsychological measures, serum and stool analyses. We hypothesise that probiotic administration will have positive effects on the gut microbiota and the treatment of AN by improvement of weight gain, gastrointestinal complaints and psychopathology, and reduction of inflammatory processes compared to placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>If probiotics could help to normalise the MI composition, reduce inflammation and gastrointestinal discomfort and increase body weight, its administration would be a readily applicable additional component of multi\u2010modal AN treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2876","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T03:49:11Z","timestamp":1638330551000},"page":"61-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa\u2014A study protocol for a longitudinal, double\u2010blind, randomized, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"30","author":[{"given":"Eva\u2010Maria","family":"Gr\u00f6bner","sequence":"first","affiliation":[{"name":"Eating Disorders Unit at the Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-6134","authenticated-orcid":false,"given":"Michael","family":"Zeiler","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit at the Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-7666","authenticated-orcid":false,"given":"Florian Ph. 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