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Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Fat\u2010free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating on why some individuals with ED symptoms progress to develop threshold EDs while others do not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.2889","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T23:19:41Z","timestamp":1645139981000},"page":"221-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6080-257X","authenticated-orcid":false,"given":"Mohamed","family":"Abdulkadir","sequence":"first","affiliation":[{"name":"Department of Pediatrics Gynaecology and Obstetrics Faculty of Medicine, University of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry Faculty of Medicine, University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-8287","authenticated-orcid":false,"given":"Christopher","family":"H\u00fcbel","sequence":"additional","affiliation":[{"name":"Social, Genetic &amp; Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London London UK"},{"name":"UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, South London and Maudsley Hospital London UK"},{"name":"National Centre for Register\u2010based Research, Aarhus Business and Social Sciences, Aarhus University Aarhus Denmark"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-5070","authenticated-orcid":false,"given":"Moritz","family":"Herle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Health Informatics Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-5087","authenticated-orcid":false,"given":"Ruth J. F.","family":"Loos","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Charles Bronfman Institute for Personalized Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-1792","authenticated-orcid":false,"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"Social, Genetic &amp; Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London London UK"},{"name":"UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, South London and Maudsley Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-3264","authenticated-orcid":false,"given":"Cynthia M.","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Nutrition University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2273","authenticated-orcid":false,"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gynaecology and Obstetrics Faculty of Medicine, University of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry Faculty of Medicine, University of Geneva Geneva Switzerland"},{"name":"Great Ormond Street Institute of Child Health, University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041187"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa","volume":"46","author":"Adams D. 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