{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:29Z","timestamp":1786977749765,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00382"],"award-info":[{"award-number":["PI16\/00382"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Up to 20% of the cases of anorexia nervosa (AN) are chronic and treatment\u2010resistant. Recently, the efficacy of deep brain stimulation (DBS) for severe cases of AN has been explored, with studies showing an improvement in body mass index and other psychiatric outcomes. While the effects of DBS on cognitive domains have been studied in patients with other neurological and psychiatric conditions so far, no evidence has been gathered in AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight patients with severe, chronic, treatment\u2010resistant AN received DBS either to the nucleus accumbens (NAcc) or subcallosal cingulate (SCC; four subjects on each target). A comprehensive battery of neuropsychological and clinical outcomes was used before and 6\u2010month after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Although Body Mass Index (BMI) did not normalise, statistically significant improvements in BMI, quality of life, and performance on cognitive flexibility were observed after 6\u00a0months of DBS. Changes in BMI were related to a decrease in depressive symptoms and an improvement in memory functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These findings, although preliminary, support the use of DBS in AN, pointing to its safety, even for cognitive functioning; improvements of cognitive flexibility are reported. DBS seems to exert changes on cognition and mood that accompany BMI increments. Further studies are needed better to determine the impact of DBS on cognitive functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.2895","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:54:39Z","timestamp":1648079679000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cognitive and quality\u2010of\u2010life related factors of body mass index (BMI) improvement after deep brain stimulation in the subcallosal cingulate and nucleus accumbens in treatment\u2010refractory chronic anorexia nervosa"],"prefix":"10.1002","volume":"30","author":[{"given":"V\u00edctor","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM) Parce de Salut Mar  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Villalba\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-4242","authenticated-orcid":false,"given":"Matilde","family":"Elices","sequence":"additional","affiliation":[{"name":"Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM) Parce de Salut Mar  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Manero","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital del Mar  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificaci\u00f3n","family":"Salgado","sequence":"additional","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Gin\u00e9s","sequence":"additional","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cedr\u00f3n","sequence":"additional","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Polo","sequence":"additional","affiliation":[{"name":"Institut de Neuropsiquiatria i Addiccions (INAD) Parc de Salut Mar Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Delgado\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Conesa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital del Mar  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Portella","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM  Madrid Spain"},{"name":"Institut de d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau. Hospital de la Santa Creu i Sant Pau. UAB  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.11.010"},{"key":"e_1_2_11_4_1","volume-title":"Barratt impulsiveness scale","author":"Barratt E. S.","year":"1975"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12110287"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.390"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2012.02.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1076\/clin.13.1.30.1976"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09010071"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082208"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22099"},{"key":"e_1_2_11_13_1","unstructured":"Gandek B. &Ware J.(1993).SF\u201036 Health Survey: Manual and interpretation guide. In:B.Gandek &J.Ware(Eds).The Health Institute New England Medical Center."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.583940"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2016.01.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000228759.95237.78"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.11.016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_85"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.578216"},{"key":"e_1_2_11_23_1","article-title":"Tower of London procedure: A standard method and developmental data. Journal of clinical and experimental neuropsychology aging and memory for names view project neuropsychology of bipolar disorder view project","author":"Krikorian R.","year":"1995","journal-title":"Articles Journal of Clinical and Experimental Neuropsychology [Internet]"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348321"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20117"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERV.0000028081.40907.de"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30076-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0128-2"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20358"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-019-00742-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(94)90002-7"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181710927"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048230"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2017.1407765"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22263"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp027"},{"issue":"169","key":"e_1_2_11_37_1","first-page":"1","article-title":"The utility of deep brain stimulation surgery for treating eating disorders: A systematic review","volume":"12","author":"Potes M. I.","year":"2021","journal-title":"Surgical Neurology International [Internet]"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130295"},{"issue":"18","key":"e_1_2_11_39_1","first-page":"1","article-title":"Literature review of cognitive neuroscience and anorexia nervosa","volume":"18","author":"Reville M.\u2010C.","year":"2016","journal-title":"Current Psychiatry Reports [Internet]"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707009877"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061108"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.11.076"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs032"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1284"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704104086"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020462"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.04.005"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.12.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061946"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-375035-8.10004-7"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359104511404750"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.06.039"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1348\/174866409X459674"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.2895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/erv.2895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.2895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:31:17Z","timestamp":1692847877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.2895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/erv.2895"],"URL":"https:\/\/doi.org\/10.1002\/erv.2895","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"2021-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}