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The aim of this study was to examine if structural measures were correlated to ASD traits in AN. In total 184 female participants participated in the study; 57 acutely underweight AN participants (AAN), 59 weight\u2010restored participants (WR) and 68 HC. Participants underwent structural magnetic resonance imaging as well as completing the Autism Diagnostic Observation schedule, second edition to examine ASD characteristics. Group differences in curvature, gyrification, surface area, thickness, global grey matter and white matter were measured. Correlation and regression analysis were conducted to examine the relationship between cortical measures and ASD characteristics. Two decreased gyrification clusters in the right post central and supramarginal gyrus and decreased global grey matter were observed in the AAN group compared to HC and WR. No correlations between ASD traits and structural measures existed. Our results suggest structural differences seen in individuals with AN do not appear to be related to ASD characteristics.<\/jats:p>","DOI":"10.1002\/erv.2910","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T04:13:51Z","timestamp":1652674431000},"page":"459-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-3179","authenticated-orcid":false,"given":"Daniel","family":"Halls","sequence":"first","affiliation":[{"name":"King's College London (KCL), Institute of Psychiatry Psychology and Neuroscience (IoPPN) Psychological Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-4375","authenticated-orcid":false,"given":"Jenni","family":"Leppanen","sequence":"additional","affiliation":[{"name":"King's College London Centre for Neuroimaging Sciences  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-8307","authenticated-orcid":false,"given":"Jess","family":"Kerr\u2010Gaffney","sequence":"additional","affiliation":[{"name":"King's College London (KCL), Institute of Psychiatry Psychology and Neuroscience (IoPPN) Psychological Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mima","family":"Simic","sequence":"additional","affiliation":[{"name":"South London and Maudsley NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasha","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-5808","authenticated-orcid":false,"given":"William","family":"Mandy","sequence":"additional","affiliation":[{"name":"Division of Psychology and Language Sciences University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Williams","sequence":"additional","affiliation":[{"name":"King's College London Centre for Neuroimaging Sciences  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-3265","authenticated-orcid":false,"given":"Kate","family":"Tchanturia","sequence":"additional","affiliation":[{"name":"King's College London (KCL), Institute of Psychiatry Psychology and Neuroscience (IoPPN) Psychological Medicine  London UK"},{"name":"South London and Maudsley NHS Foundation Trust  London UK"},{"name":"Psychology Department Illia State University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291716001082"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010016\u20100856\u2010z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.05.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170072"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u201011\u2010179"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2020.111069"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216154"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.02.131"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00408"},{"key":"e_1_2_10_14_1","volume-title":"ENIGMA Cortical Quality Control Protocol 2.0","year":"2017"},{"key":"e_1_2_10_15_1","first-page":"309","volume-title":"Cognitive behavior therapy and eating disorders","author":"Fairburn C. 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