{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:05:38Z","timestamp":1790442338767,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Theory of mind (ToM) is important for social interactions and typical development and has been found to be impaired in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Hypoactivation in frontotemporal brain regions seems to be the underlying neural mechanism in AN while whole\u2010brain analyses in BN are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the well\u2010validated social recognition task fMRI paradigm to assess ToM in a total of 72 female adolescents\u00a0(16 BN, 18 AN and 38 matched healthy controls [HC]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HC<jats:sub>BN<\/jats:sub>, patients with BN showed hyperactivity during ToM\u2010activity in the right frontal pole, middle temporal gyrus and left temporal pole and differed fundamentally from hypoactivation in these regions observed in patients with AN before and after short\u2010term weight rehabilitation. Interaction and overlap analyses confirmed that similar regions were affected in opposite directions in both diseases. Hyperactivations in BN in the right middle temporal gyrus and right frontal pole were associated with clinical BN\u2010severity markers binging and purging frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The hyperactivation in BN suggest different underlying neural mechanisms for ToM compared to AN. Hyperactivity might correspond to a different but also ineffective cognitive style in patients with BN when approaching social interactions. These important transdiagnostic differences are relevant for future brain\u2010targeted therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2911","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T01:04:20Z","timestamp":1655255060000},"page":"486-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neural mechanisms underlying social recognition and theory of mind in adolescent patients with bulimia nervosa and transdiagnostic comparison with anorexia nervosa"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-5189","authenticated-orcid":false,"given":"Vanessa Ande","family":"Ruan","sequence":"first","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"},{"name":"Clinic for Obstetrics Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Hartz","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Hueck","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Dahmen","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"von Polier","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"},{"name":"Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Institute of Neuroscience and Medicine Brain &amp; Behaviour (INM\u20107) Reseaerch Centre J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-3323","authenticated-orcid":false,"given":"Beate","family":"Herpertz\u2010Dahlmann","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Konrad","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics Child Neuropsychology Section University Hospital Aachen  Aachen Germany"},{"name":"Institute of Neurosciences and Medicine J\u00fcllich Molecular Neuroscience and Neuroimaging (INM\u201011) Research Centre J\u00fcllich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schulte\u2010R\u00fcther","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics Child Neuropsychology Section University Hospital Aachen  Aachen Germany"},{"name":"Institute of Neurosciences and Medicine J\u00fcllich Molecular Neuroscience and Neuroimaging (INM\u201011) Research Centre J\u00fcllich  J\u00fclich Germany"},{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Seitz","sequence":"additional","affiliation":[{"name":"Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0885\u20102014(00)00014\u20109"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.1152"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2594"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1302"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1884"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.10.009"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22572"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100690"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.07.002"},{"key":"e_1_2_15_12_1","volume-title":"Strukturiertes Inventar f\u00fcr anorektische und bulimische E\u00dfst\u00f6rungen (SIAB): Fragebogen (SIAB\u2010S) und Interview (SIAB\u2010EX) nach DSM\u2010IV und ICD\u201010; 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