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Cognitive Remediation Therapy (CRT), mainly evaluated in adults with AN, targets these impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescent inpatients (age\u00a0=\u00a011\u201317\u00a0years) with AN were randomized to 5\u00a0weeks of either 10 sessions of individually delivered CRT or non\u2010specific cognitive\u2010training (NSCT). Co\u2010primary outcomes included cognitive domain \u2018flexibility\u2019 [composite score of Wisconsin Card Sorting Test (WSCT) and Trail Making Test (TMT\u20104)] and \u2018central coherence\u2019 [composite score of Central Coherence Index (CCI) and Group Embedded Figures Test (GEFT)] at end of treatment (FU1). Secondary outcomes included individual test scores and self\u2010reported everyday\u2010life flexibility at FU1 and at 6\u2010months post\u2010treatment (FU2). Independent sample <jats:italic>t<\/jats:italic>\u2010tests, Pearson chi\u2010square\u2010tests and mixed models for repeated measures (MMRM) analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 56 females (age\u00a0=\u00a015.1\u00a0\u00b1\u00a01.5\u00a0years), CRT was not superior to NSCT at FU1 regarding \u2018flexibility\u2019 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.768) or \u2018central coherence\u2019 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.354), nor at FU2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.507; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.624) (effect sizes\u00a0=\u00a00.02\u20130.26). Both groups improved over time in central coherence (CCI <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; GEFT <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), self\u2010reported flexibility (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and WCST (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.18), but not TMT\u20104 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.286). NSCT was superior to CRT regarding self\u2010reported planning\/organisation ability at FU1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and FU2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRT was not superior to NSCT in adolescent inpatients with AN. More randomized controlled studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2921","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T05:08:38Z","timestamp":1653368918000},"page":"772-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Randomized controlled trial of cognitive remediation therapy in adolescent inpatients with anorexia nervosa: Neuropsychological outcomes"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-1389","authenticated-orcid":false,"given":"Laura","family":"Herbrich\u2010Bowe","sequence":"first","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"Bentz","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Germany"},{"name":"Department of Psychiatry Northwell Health  Glen Oaks New York USA"},{"name":"Department of Psychiatry and Molecular Medicine Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"},{"name":"Center for Psychiatric Neuroscience The Feinstein Institute for Medical Research  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Kappel","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betteke M.","family":"van Noort","sequence":"additional","affiliation":[{"name":"Department of Psychology MSB Medical School Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_8_3_1","volume-title":"Local\u2013global processing and cognitive style in autism spectrum disorders and typical development","author":"Booth R.","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22206"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000675"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010012\u20100821\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20956"},{"key":"e_1_2_8_8_1","volume-title":"Delis\u2013Kaplan executive function system (D\u2013KEFS)","author":"Delis D.","year":"2001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355240"},{"key":"e_1_2_8_10_1","volume-title":"BRIEF. 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