{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:53:25Z","timestamp":1790733205950,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies of AN showed low\u2010grade inflammation. Are low\u2010grade inflammation and circulating lymphocytes associated with chronic conditions?<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Peripheric blood cytokines were measured using Luminex\u2122 technology in a chronic AN cohort (mean\u00a0=\u00a067.42\u00a0months), compared to Constitutional Thinness (CT), Constitutional Obesity (CO), and Healthy Controls (HC). Secondarily a prospective cohort of chronic AN (mean\u00a0=\u00a054.11\u00a0months) was recruited to compare the functional lymphocyte profile in blood by flow cytometry to CT and HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the AN group, most cytokine concentrations were lower than in CT and HC groups. The IL\u201023 (98.02 pg\/ml) was elevated related to HC and CO, and the IL\u201010 (4.178 pg\/ml) was elevated versus CO. In the CT group, IL\u20109 (0.06216 pg\/ml) was elevated compared to AN. The AN group had high Treg (9.259% of CD4<jats:sup>+<\/jats:sup>) and CD8<jats:sup>+<\/jats:sup>Integrin\u03b27<jats:sup>+<\/jats:sup> (9.552% of CD3<jats:sup>+<\/jats:sup>) versus HC for lymphocyte populations. In CT group, elevated Treg (9.7% of CD4<jats:sup>+<\/jats:sup>) elevated percentage of CD4<jats:sup>+<\/jats:sup>CCR9<jats:sup>+<\/jats:sup> (5.867% of CD3<jats:sup>+<\/jats:sup>) and CD8<jats:sup>+<\/jats:sup>Integrin\u03b27<jats:sup>+<\/jats:sup> (10.21% of CD3<jats:sup>+<\/jats:sup>) were found versus HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The chronic state of AN and CT is surprisingly non\u2010inflammatory with elevated Treg cells. These results suggest that maintaining a dysregulated response to intestinal antigens may contribute to maintaining AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2934","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T17:53:41Z","timestamp":1656179621000},"page":"76-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of gut\u2010specific non\u2010inflammatory T lymphocytes with chronic anorexia nervosa and constitutional thinness"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-0588","authenticated-orcid":false,"given":"Tristan","family":"Gabriel","sequence":"first","affiliation":[{"name":"CIRI \u2013 Centre International de Recherche en Infectiologie, Team GIMAP Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530  Saint\u2010Etienne 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