{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:20:55Z","timestamp":1790781655342,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anorexia nervosa (AN) is an eating disorder characterised by voluntary dietary restriction leading to severe undernutrition. Hypoglycaemia is mostly described through severe case reports and is always evaluated by fasting or post\u2010meal blood glucose, showing nothing about hypoglycaemia's length or duration. The interest of continuous interstitial glucose monitoring (CGM), largely used in diabetes mellitus, has never been evaluated in AN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Glycaemia cycles in AN patients were assessed using CGM over 5\u00a0days and then analysed according to food intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean glycaemia was within normal range. 91% of the patients presented with at least one episode with glycaemia under 70\u00a0mg\/dl. Within the 24\u00a0h, the percentage of time spent with a glycaemia under 70\u00a0mg\/dl was of 20.82\u00a0\u00b1\u00a03.90% with a maximum of 52%. We found 2.52\u00a0\u00b1\u00a00.33 hypoglycaemia events per 24\u00a0h, including 21.11\u00a0\u00b1\u00a03.76% at night. CGM parameters correlated with cortisol and IGF1 plasma levels. Comparison with estimated carbohydrate intakes discriminated concordant and non\u2010concordant estimations depending on patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AN patients display chronic prolonged mild hypoglycaemia all over the nycthemeron despite normal fasting glycaemia. Associated adaptive increased counter\u2010regulatory hormones might protect AN patients from deeper hypoglycaemia. CGM allowed testing food intake self\u2010estimation reliability of AN patients and could be a very useful biofeedback tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2963","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T12:05:01Z","timestamp":1671624301000},"page":"402-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Continuous glucose monitoring assessment in patients suffering from anorexia nervosa reveals chronic prolonged mild hypoglycemia all over the nycthemeron"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-7244","authenticated-orcid":false,"given":"Natacha","family":"Germain","sequence":"first","affiliation":[{"name":"Department of Endocrinology Diabetes, Metabolism and Eating Disorders University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"TAPE Research Group Jean Monnet University of 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