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This study examined whether self\u2010report and real\u2010time evoked pain experience were mediated by depression, alexithymia and interoceptive awareness in a comprehensive sample of patients with eating disorders (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>145 participants (90 ED, 55 healthy controls (HC)) underwent a real\u2010time evoked examination of pain and completed self\u2010report questionnaires for pain (Pain Detect Questionnaire (PD\u2010Q), PD\u2010Q VAS, Leeds Assessment of Neuropathic Symptoms and Signs), depression (BDI\u2010II), interoceptive awareness Multidimensional Assessment of Interoceptive Awareness (MAIA), and alexithymia (TAS\u201020). Three mediation models, with ED diagnosis as independent variable, and BDI, MAIA and TAS\u201020 as mediators, were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with ED and HC exhibited similar pain type and intensity (self\u2010report and real\u2010time). Eating disorders diagnosis was associated with lower self\u2010report pain intensity and non\u2010neuropathic like pain experience (model 1\u20132). Depressive symptoms partially (model 1\u20132) or fully (model 3) mediated the association between ED diagnosis and pain experience, alone (model 1) or via alexithymia (model 3). Interoceptive awareness did not influence pain symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>ED diagnosis is associated with non\u2010neuropathic and lower pain experience. However, concurrent depression and alexithymia are associated with higher pain symptoms and neuropathic features. 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