{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:49:51Z","timestamp":1789044591808,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017596","name":"Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Medication is commonly used in anorexia nervosa (AN) despite largely missing high grade evidence. Olanzapine (OLZ) is the best\u2010evidenced substance used off\u2010label in this group, with conflicting outcome regarding BMI, clinical and safety parameters. Therefore, it is important to strictly assure quality of treatment with OLZ in AN by using \u2018Therapeutic Drug Monitoring\u2019 according to AGNP\u2010guidelines, including serum levels and adverse drug reactions (ADRs) to support safety for adolescents with AN and attempt to generate an initial age\u2010 and disorder\u2010specific therapeutic reference range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010five adolescents with AN (aged 10\u201318) treated with OLZ (98% female; 97.5% AN\u2010restricting\u2010type) were prospectively observed, ADRs reported, and correlations between dosage and serum levels measured at trough level were calculated, a preliminary therapeutic range defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean dosage of OLZ was 8.15 (SD: 2.91) mg and 0.19 (SD: 0.07) mg\/kg respectively, average concentration was 26.57 (SD: 13.46) ng\/mL. Correlation between daily dosage\/dosage per kg and serum level was 0.72 (**<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001)\/0.65 (**<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), respectively. ADRs with impairment were rare (6.3%). 75% improved clinically (CGI). BMI increased significantly by 1.5\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>t<\/jats:italic>\u00a0=\u00a010.6, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). A preliminary therapeutic reference range is 11.9 and 39.9\u00a0ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OLZ in the hands of specialists is a well\u2010tolerated and safe treatment adjunct for adolescents with AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.3022","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:19:41Z","timestamp":1692638381000},"page":"1055-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic drug monitoring in adolescents with anorexia nervosa for safe treatment with adjunct olanzapine"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-998X","authenticated-orcid":false,"given":"Andreas","family":"Karwautz","sequence":"first","affiliation":[{"name":"Eating Disorders Care and Research Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  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Department of Child and Adolescent Psychiatry Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gl\u00fcder","sequence":"additional","affiliation":[{"name":"Eating Disorders Care and Research Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Wagner","sequence":"additional","affiliation":[{"name":"Eating Disorders Care and Research Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Malcher","sequence":"additional","affiliation":[{"name":"Eating Disorders Care and Research Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Wien 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