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Mediation analyses tested relationships between ACE score, self\u2010esteem, and ED behaviours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ACE scores were elevated in EDs and correlated positively with body mass index (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), drive for thinness (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and body dissatisfaction (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032); low self\u2010esteem mediated the relationship between ACEs and body dissatisfaction, drive for thinness, and bulimia severity. ACE scores correlated negatively (FDR\u2010corrected) with unexpected, salient stimulus receipt in AN (substantia nigra) and BN (anterior cingulate, frontal and insular cortex, ventral striatum, and substantia nigra). When ACE scores were included in the model, unexpected stimulus receipt brain response was elevated in EDs in the anterior cingulate and ventral striatum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACEs attenuate unexpected salient stimulus receipt response, which may be a biological marker for altered valence or hedonic tone perception in EDs. Low self\u2010esteem mediates the relationships between ACEs and ED behaviours. Adverse childhood experiences should be assessed in biological studies, and their effects targeted in treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.3064","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T13:44:20Z","timestamp":1707831860000},"page":"618-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adverse childhood experiences, low self\u2010esteem, and salient stimulus response in eating disorders"],"prefix":"10.1002","volume":"32","author":[{"given":"Sarah","family":"Lagan","sequence":"first","affiliation":[{"name":"University of California San Diego School of Medicine  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Shott","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-3441","authenticated-orcid":false,"given":"Guido K. 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