{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:25:15Z","timestamp":1780467915262,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Eating disorders (ED) typically emerge in adolescence, a critical period for brain development and peer bonding. Interpersonal difficulties\u2014particularly social anxiety\u2014frequently co\u2010occur with ED. Oxytocin is a neuropeptide that modulates social cognition and linked to prosocial effects. To date, no study has investigated oxytocin's effects on negative interpretation bias toward ambiguous information in adolescents with ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight female adolescents aged 16 to 17\u00a0years with and without EDs took part in a placebo\u2010controlled, double\u2010blinded, randomised, crossover trial investigating the effects of 24 IU intranasal oxytocin on negative interpretations of ambiguous scenarios. Participants and controls were tested twice, approximately one week apart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Contrary to hypothesis, oxytocin increased negative interpretations overall (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019, large effect). Adolescent females with AN or BN made more negative interpretations than controls when presented with ambiguous information. There was no group effect for those who reached or did not reach threshold on an autism screen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests adolescents with EDs interpret ambiguous information more negatively than controls and that oxytocin administration amplifies negative responses to ambiguity in adolescent females, including in controls. Research tools that effectively identify these biases would help to widen the scope of ED treatments for adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.3167","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:53:59Z","timestamp":1738277639000},"page":"691-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-3640","authenticated-orcid":false,"given":"Victoria","family":"Burmester","sequence":"first","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-9548","authenticated-orcid":false,"given":"Emerie","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0815-0351","authenticated-orcid":false,"given":"Nikita Catalina","family":"Julius","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0665-4019","authenticated-orcid":false,"given":"Jordan","family":"Elliott","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Thackeray","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-6605","authenticated-orcid":false,"given":"Dasha","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Faculty of Medicine Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953\u20108194.2004.01161.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16214177"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.34"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005653411471"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.05.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721417738144"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2523"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112704"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mhs2.34"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x16666180118100028"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2493"},{"key":"e_1_2_8_15_1","unstructured":"Chorpita B. F. C.Ebesutani andS. H.Spence.2015.Revised Children\u2019s Anxiety and Depression Scale: H\u00e4mtad fr\u00e5nhttps:\/\/www.childfirst.ucla.edu\/wpcontent\/uploads\/sites\/163\/2018\/03\/RCADSUsersGuide20150701.pdf."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010psych\u2010010419\u2010050937"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004569\u20105"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.11.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0005\u20107967(02)00088\u20108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14616734.2013.850103"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022898"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2012.07.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(03)00465\u20107"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.019"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.06.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23704"},{"key":"e_1_2_8_28_1","article-title":"Less Is More: A Dose\u2010Response Mechanistic Account of Intranasal Oxytocin Pharmacodynamics in the Human Brain","author":"Martins D.","year":"2021","journal-title":"bioRxiv"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014845\u20105"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1380"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12963"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102826.2006.01525.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.06.019"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010109400"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(20)30186\u20103"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608\u2010016\u20109760\u20106"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159910"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010021\u201000460\u20102"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5039\u201008.2009"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.07.013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000742"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00161"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.07.020"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/26408066.2022.2117582"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13255"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000219"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.12.2.123"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.089"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.13109\/zptm.2005.51.1.57"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u20103514.91.5.918"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010022\u201006187\u20105"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010021\u201000387\u20108"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.3167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:24:58Z","timestamp":1763645098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.3167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/erv.3167"],"URL":"https:\/\/doi.org\/10.1002\/erv.3167","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}