{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:54:15Z","timestamp":1792187655226,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review explores the associations between qualitative\/quantitative changes in gut microbiota and psychopathological symptoms or other clinical features in patients with eating disorders (EDs). Secondary outcomes include exploring gut microbiota changes in EDs and potential relationships with psychotropic drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic search was conducted across biomedical databases from inception to June 2024 according to PRISMA guidelines. The risk of bias was assessed, and a narrative synthesis was performed due to the heterogeneity of the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Only findings related to anorexia nervosa (AN) were identified. Ten studies, of which seven were longitudinal, two cross\u2010sectional, and one interventional (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0350 patients with AN, and 304 HCs), were included. Despite no clear links between diversity metrics and clinical symptoms being observed, specific taxa belonging to phylum Firmicutes, such as\n                      <jats:italic>Clostridium<\/jats:italic>\n                      ,\n                      <jats:italic>Roseburia<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ,\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      belonging to Actinobacteriota correlated with ED psychopathology, including anxiety and depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Changes in microbiota were related to anxiety and depressive symptoms, as well as altered eating behaviours by modulating inflammation and insulin pathways through short\u2010chain fatty acids (SCFAs), that also lead to neurotransmitter imbalances. Further studies are required to replicate these finding and to explore whether similar patterns are observed in other EDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.3179","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:59:56Z","timestamp":1738277996000},"page":"700-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Unlocking the Link Between Gut Microbiota and Psychopathological Insights in Anorexia Nervosa: A Systematic Review"],"prefix":"10.1002","volume":"33","author":[{"given":"Mauro","family":"Scala","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM) Alma Mater Studiorum\u2010University of Bologna  Bologna Italy"},{"name":"Faculty of Biomedical and Health Sciences European University of Madrid  Madrid Spain"},{"name":"Division of Neuroscience Health Research Institute Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"Department of Legal Medicine, Pathology, and Psychiatry Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Tabone","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences European University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paolini","sequence":"additional","affiliation":[{"name":"Division of Neuroscience Psychiatry and Clinical Psychobiology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salue\u00f1a","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences European University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo Arroyo","family":"Iturra","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Pathology, and Psychiatry Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Romero","family":"Ferreiro","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences European University of Madrid  Madrid Spain"},{"name":"Division of Neuroscience Health Research Institute Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"CIBERSAM\/ISCIII (Biomedical Research Networking Centre in Mental Health)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Alvarez\u2010Mon","sequence":"additional","affiliation":[{"name":"CIBERSAM\/ISCIII (Biomedical Research Networking Centre in Mental Health)  Madrid Spain"},{"name":"Department of Medicine and Medical Specialities University of Alcala  Alcala de Henares Spain"},{"name":"Department of Psychiatry and Mental Health Infanta Leonor University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-3759","authenticated-orcid":false,"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Kore University of Enna  Enna Italy"},{"name":"Oasi Research Institute\u2010IRCCS  Troina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Roc\u00edo Gonzalez","family":"Soltero","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences European University of Madrid  Madrid Spain"},{"name":"Molecular Microbiology Group Health Research Institute of the University Hospital La Paz (IdiPAZ) Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rodriguez\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Division of Neuroscience Health Research Institute Hospital 12 de Octubre (imas12)  Madrid Spain"},{"name":"Department of Legal Medicine, Pathology, and Psychiatry Complutense University of Madrid (UCM)  Madrid Spain"},{"name":"CIBERSAM\/ISCIII (Biomedical Research Networking Centre in Mental Health)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(24)00127\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207618"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2304158"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007125"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.3069"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000533"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179739"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.02.009"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"11","article-title":"A Cross\u2010Cultural Examination of the Relationship Between Negative Mood States, Body Image and Eating Disorders","author":"Brytek\u2010Matera A.","year":"2009","journal-title":"Bull Soc Sci Med Grand Duche Luxemb"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2021.0188"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2020.109"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.116115"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2016_6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.115914"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110114"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010023\u201001355\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.04.060"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20146325"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010023\u201001529\u20104"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.611677"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10096"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105179"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201077085\u2010z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001209\u2010w"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099\u2010020\u20100346\u20101"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2018.10.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102024\u2010079890"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002428\u2010z"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291724000394"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060891"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010012\u20102197\u20101"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/psy.0000000000000247"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/prbm.s411112"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26752"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530318666180213111637"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20924"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13270"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(13)70180\u20103"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010022\u201001116\u20103"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.07.021"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296037"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145274"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22801"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2021.105799"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12378"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.08.026"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.656895"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14112037"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2023.07.010"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12811"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.06.009"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1902771"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7090338"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010023\u201000833\u20109"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602187103"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000488"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.11.004"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23435"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000818"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2020.101943"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.06.011"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.806327"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.01.007"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30059\u20103"},{"key":"e_1_2_10_73_1","volume-title":"International Classification of Diseases","author":"World Health Organization (WHO)","year":"2022"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100729\u20101"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology31010006"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2215\u20100366(15)00356\u20109"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.3179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:24:54Z","timestamp":1763645094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.3179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/erv.3179"],"URL":"https:\/\/doi.org\/10.1002\/erv.3179","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}