{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:21:47Z","timestamp":1791343307859,"version":"4.3.1"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eating disorders (EDs) are serious psychiatric disorders characterized by impairments in neurocognition and altered brain structure. To date the majority of studies have investigated these in acutely ill or recovered individuals. Studying children at familial high risk (FHR) for psychiatric disorders allows investigating vulnerability traits or trait markers that may be present before disorder onset. Our study is the first one to examine executive function and brain structure in girls at FHR for ED (Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder) compared to controls (girls not at familial high risk \u2010 HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010six (46) FHR girls (median age: 10.5\u00a0years, range: 9) and 50 HC girls (median age: 12\u00a0years, range: 8) completed a battery of neuropsychological tests assessing cognitive flexibility, inhibitory control, and working memory. Structural magnetic resonance imaging assessed grey matter volume (GMV) and cortical thickness (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Girls at FHR for ED performed a higher number of errors in a cognitive flexibility task compared to HC (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). They also had increased GMV in posterior regions such as the right supramarginal gyrus, middle occipital gyrus, and lingual\/fusiform gyrus compared to HC (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 cluster\u2010level FWE\u2010corrected), as well as increased CT in the left transverse pole (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and right posterior cingulate cortex (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Girls at FHR show characteristic neurocognitive performance similar to that seen in individuals with ED, as well as differences in brain structure compared to HC. Our findings, together with previous evidence, highlight impairment in cognitive flexibility as a possible trait marker of ED. Further longitudinal studies are needed to confirm differences in GMV and CT identified in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.3203","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:28:34Z","timestamp":1745540914000},"page":"1032-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurobiology and Cognition in Girls at High\u2010Risk of Eating Disorders: Exploring Imaging\u2010Derived Trait Markers"],"prefix":"10.1002","volume":"33","author":[{"given":"E.","family":"Pappaianni","sequence":"first","affiliation":[{"name":"Center for Eating and Feeding Disorders Research (CEDaR) Mental Health Center Ballerup Copenhagen University Hospital\u2014Mental Health Services CPH  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Borsarini","sequence":"additional","affiliation":[{"name":"Network Plasticity Modulation (NetPM) Lab Department of Clinical Neurosciences Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Berchio","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience Group of Psychiatric Neuroscience University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aicoboaie","sequence":"additional","affiliation":[{"name":"Center for Eating and Feeding Disorders Research (CEDaR) Mental Health Center Ballerup Copenhagen University Hospital\u2014Mental Health Services CPH  Copenhagen Denmark"},{"name":"Institute of Biological Psychiatry Mental Health Centre Sct Hans Copenhagen University Hospital \u2010 Mental Health Services  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Konstantopoulou","sequence":"additional","affiliation":[{"name":"Network Plasticity Modulation (NetPM) Lab Department of Clinical Neurosciences, Faculty of Medicine, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Van de ville","sequence":"additional","affiliation":[{"name":"Neuro\u2010X Institute \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Geneva Switzerland"},{"name":"Department of Radiology and Medical Informatics University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2273","authenticated-orcid":false,"given":"N.","family":"Micali","sequence":"additional","affiliation":[{"name":"Center for Eating and Feeding Disorders Research (CEDaR) Mental Health Center Ballerup Copenhagen University Hospital\u2014Mental Health Services CPH  Copenhagen Denmark"},{"name":"Institute of Biological Psychiatry Mental Health Centre Sct Hans Copenhagen University Hospital \u2010 Mental Health Services  Copenhagen Denmark"},{"name":"Great Ormond Street Institute of Child Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.10.032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_4_1","volume-title":"Structured Clinical Interview for DSM\u20105, Research Version (SCID\u20105\u2010RV)","author":"American Psychiatric Association","year":"2015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002586\u20100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140193"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.08.022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22572"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1092852920001674"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721418787475"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010022\u201000547\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01651"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2018.10.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001071\u2010z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010022\u201001483\u20107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010022\u201001370\u20101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.050"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2021.09.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_10_22_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u20105)","year":"2013"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010psych\u2010113011\u2010143750"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110649"},{"key":"e_1_2_10_25_1","first-page":"E297","article-title":"Gene Variants in Eating Disorders. 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