{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:57:36Z","timestamp":1792144656747,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017596","name":"Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte","doi-asserted-by":"publisher","award":["73.05\/3832\u2013397285\/12"],"award-info":[{"award-number":["73.05\/3832\u2013397285\/12"]}],"id":[{"id":"10.13039\/100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality, requiring innovative treatment strategies. Olanzapine (OLZ), an atypical antipsychotic, has demonstrated efficacy in promoting weight gain and reducing psychopathological symptoms in adults with AN. However, its efficacy and safety in adolescents remain insufficiently explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study assessed the impact of adjunctive OLZ in adolescents with AN during inpatient care, focussing on weight gain, eating disorder pathology, and metabolic safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A naturalistic, prospective study compared two groups of adolescent inpatients with AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a047 each), one receiving standard multidisciplinary care plus OLZ and one receiving standard care alone (Non\u2010OLZ). Weekly weight gain as well as admission\u2010to\u2010discharge changes in body\u2010mass\u2010index, eating disorder symptoms, and metabolic markers were compared between the two cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The OLZ group (\u2205 9\u00a0mg\/day) achieved greater weekly weight gain (0.898 vs. 0.677\u00a0kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) compared to the Non\u2010OLZ group. Both groups showed similar reductions in eating disorder pathology; however, improvements in body dissatisfaction were larger in the Non\u2010OLZ group. Administration of OLZ was associated with significant prolactin level increases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OLZ is a promising adjunctive treatment for adolescents in terms of supporting weight gain during inpatient care. However, psychological effects and possible metabolic risks warrant further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70009","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T04:59:58Z","timestamp":1752123598000},"page":"1314-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Adjunct Olanzapine Treatment in Adolescents With Anorexia Nervosa: A Comparison of Two Patient Cohorts"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5321-6043","authenticated-orcid":false,"given":"Helene","family":"Krauss","sequence":"first","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-6134","authenticated-orcid":false,"given":"Michael","family":"Zeiler","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunja","family":"Mairhofer","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-6865","authenticated-orcid":false,"given":"Julia","family":"Klang","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schwarzenberg","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Mitterer","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9684","authenticated-orcid":false,"given":"Gudrun","family":"Wagner","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gl\u00fcder","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-0954","authenticated-orcid":false,"given":"Karin","family":"Egberts","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy Centre for Mental Health University Hospital of Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy Centre for Mental Health University Hospital of Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-998X","authenticated-orcid":false,"given":"Andreas","family":"Karwautz","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0139"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18101125"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v65n1106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102436\u20109552"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328080ca31"},{"key":"e_1_2_11_8_1","first-page":"4","article-title":"Sicherheit von Psychopharmaka bei Kindern und Jugendlichen in der klinischen Praxis\u2014Erkenntnisse einer prospektiven Studie","volume":"3","author":"Egberts K.","year":"2020","journal-title":"Bulletin zur Arzneimittelsicherheit"},{"key":"e_1_2_11_9_1","volume-title":"Binge Eating: Nature, Assessment, and Treatment","author":"Fairburn C. 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