{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:38Z","timestamp":1792511018056,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates clinical heterogeneity in patients with binge eating disorder (BED) and its association with treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010step cluster analysis was conducted on a clinical sample of 196 BED patients, using an agglomerative hierarchical procedure based on both categorical and quantitative measures\u2014psychopathological symptoms, personality traits, emotional dysregulation, body composition, and food addiction. A subsequent comparison between clusters assessed therapy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two distinct clusters emerged: C1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a077) and C2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0119). C2 patients exhibited a more dysfunctional profile, marked by more frequent binge episodes, higher eating psychopathology, greater emotion regulation difficulties, higher impulsivity levels, worse psychopathological state, higher food addiction levels, and personality traits reflecting greater harm avoidance and lower self\u2010directedness and cooperativeness. While clusters did not differ by age, C2 had earlier age of onset and longer duration of the disorder. In contrast, C1 showed a more functional profile, later age of onset, lower total body fat mass, and better treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight heterogeneity in BED, particularly regarding age of onset and associated clinical features, which may influence treatment response. The results suggest the need for distinct treatment strategies and more personalised therapeutic approaches tailored to patient subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70034","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:15:31Z","timestamp":1759565731000},"page":"375-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Addressing Heterogeneity in Binge Eating Disorder: A Cluster Analysis Approach Based on Age of Onset, Clinical and Psychopathological Features"],"prefix":"10.1002","volume":"34","author":[{"given":"Luc\u00eda","family":"Camacho\u2010Barcia","sequence":"first","affiliation":[{"name":"Clinical Psychology Department Bellvitge University Hospital  Barcelona Spain"},{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Ciber Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn) Instituto de Salud Carlos III  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia T.","family":"S\u00e1nchez\u2010Salido","sequence":"additional","affiliation":[{"name":"Neuroscience Department Bellvitge University Hospital  Barcelona Spain"},{"name":"Fundamental and Clinical Nursing Department School of Nursing University of Barcelona Bellvitge Campus L \u0301Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Jim\u00e9nez del","family":"Toro","sequence":"additional","affiliation":[{"name":"Clinical Psychology Department Bellvitge University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-3198","authenticated-orcid":false,"given":"Roser","family":"Granero","sequence":"additional","affiliation":[{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Ciber Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn) Instituto de Salud Carlos III  Barcelona Spain"},{"name":"Department of Psychobiology and Methodology Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Clinical Psychology Department Bellvitge University Hospital  Barcelona Spain"},{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Ciber Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn) Instituto de Salud Carlos III  Barcelona Spain"},{"name":"Department of Clinical Sciences School of Medicine and Health Sciences University of Barcelona Bellvitge Campus L \u0301Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Supit","sequence":"additional","affiliation":[{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Department of Neurobiology Faculty of Science Universiteit van Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2273","authenticated-orcid":false,"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"name":"Center for Eating and Feeding Disorders Research Mental Health Services of the Capital Region of Denmark Psychiatric Centre Ballerup  Ballerup Denmark"},{"name":"Great Ormond Street Institute of Child Health University College London  London UK"},{"name":"Psychiatric Center Sct. Hans Mental Health Services in the Capital Region of Denmark Institute of Biological Psychiatry  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin Elisabeth","family":"Giel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Centre of Excellence for Eating Disorders (KOMET) University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Centre for Mental Health (DZPG)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Jim\u00e9nez\u2010Murcia","sequence":"additional","affiliation":[{"name":"Clinical Psychology Department Bellvitge University Hospital  Barcelona Spain"},{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Ciber Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn) Instituto de Salud Carlos III  Barcelona Spain"},{"name":"Department of Clinical Sciences School of Medicine and Health Sciences University of Barcelona Bellvitge Campus L \u0301Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Centre of Excellence for Eating Disorders (KOMET) University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Centre for Mental Health (DZPG)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Fern\u00e1ndez\u2010Aranda","sequence":"additional","affiliation":[{"name":"Clinical Psychology Department Bellvitge University Hospital  Barcelona Spain"},{"name":"Psychoneurobiology of Eating and Addictive Behaviours Group Neurosciences Programme Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Ciber Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn) Instituto de Salud Carlos III  Barcelona Spain"},{"name":"Department of Clinical Sciences School of Medicine and Health Sciences University of Barcelona Bellvitge Campus L \u0301Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40211\u2010020\u201000346\u2010w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u201013\u2010285"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1556\/2006.2023.00074"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.111023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.01.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCLP.22006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.02.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11154\u2010023\u201009810\u20108"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2023.107037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.07.032"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110318"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126083"},{"key":"e_1_2_8_16_1","volume-title":"Temperament and Character Inventory\u2013Revised","author":"Cloninger C. 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