{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:32:17Z","timestamp":1791855137026,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone\/bupropion for treating binge eating disorder (BED) using network meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials evaluating these medications versus placebo in adults with BED. Primary outcomes were changes in binge eating frequency and body weight; secondary outcomes included serious adverse events, discontinuation rates, and common side effects. A frequentist random\u2010effects network meta\u2010analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve trials (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01988) met inclusion criteria. Both lisdexamfetamine (MD \u22121.61, 95% CI: \u22122.41 to \u22120.81) and topiramate (MD \u22121.63, 95% CI: \u22122.53 to \u22120.74) significantly reduced binge eating frequency versus placebo, with comparable efficacy. Topiramate produced the greatest weight loss (MD \u22125.5\u00a0kg), followed by lisdexamfetamine (\u22124.6\u00a0kg). Naltrexone\/bupropion did not significantly reduce binge frequency (MD \u22122.07, 95% CI: \u22124.45 to 0.31). Lisdexamfetamine was associated with higher risks of dry mouth and gastrointestinal events. No significant increase in serious adverse events was observed for any medication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topiramate and lisdexamfetamine are effective for reducing binge episodes and weight in BED. Naltrexone\/bupropion showed modest weight effects but lacked clear efficacy for binge reduction. These findings support topiramate and lisdexamfetamine as primary pharmacologic options for BED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70035","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:45:57Z","timestamp":1758606357000},"page":"334-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Lisdexamfetamine Versus Topiramate Versus Naltrexone\/Bupropion in Individuals With Binge Eating Disorder: A Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3119-2548","authenticated-orcid":false,"given":"Tamer","family":"Hodrob","sequence":"first","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University  East Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Ismail","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University  East Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaaeddin","family":"Abusalameh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University  East Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3351-5723","authenticated-orcid":false,"given":"Celina R.","family":"Andonie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University  East Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ayesh","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Al\u2010Aqsa University  Gaza Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-705X","authenticated-orcid":false,"given":"Hazem","family":"Ayesh","sequence":"additional","affiliation":[{"name":"Deaconess Health System  Evansville Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.18637\/JSS.V106.I02"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.591382"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLINTHERA.2020.10.014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15\u20102455"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRA.0000410982.08229.99"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/EAT.20238"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJEBM\u20102021\u2010111904"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.V68N0901"},{"key":"e_1_2_12_10_1","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions.Cochrane Training. 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