{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:49:32Z","timestamp":1775249372479,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Risk for thiamine deficiency in individuals with anorexia nervosa (AN) remains uncertain due to significant heterogeneity in limited studies and given that current treatment recommendations are based on expert opinion and research in alcoholism. The purpose of this pilot study is to better understand thiamine deficiency in individuals with extreme AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this prospective, observational, pilot study, whole blood thiamine diphosphate (TDP) levels in 24 individuals with extreme AN, without nutritional rehabilitation or micronutrient supplementation for the preceding 30\u00a0days before admission, were compared to both a reference range and whole blood TDP levels in normal\u2010weighted individuals. Individuals in the AN cohort were also provided 200\u00a0mg of oral thiamine for the first 10\u00a0days of hospitalisation, to better understand the impact of supplementation during refeeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean whole blood TDP levels were within the standard reference range and not statistically different from the control group. Whole blood TDP levels did not significantly increase after 10\u00a0days of oral thiamine supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with AN may not be at high risk for thiamine deficiency. A larger follow\u2010up study assessing whole blood TDP levels, without any recent thiamine supplementation, is required to fully understand the risk of thiamine deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70059","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:44:41Z","timestamp":1763703881000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole Blood Thiamine Levels in Extreme Anorexia Nervosa: A Pilot Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Dennis","family":"Gibson","sequence":"first","affiliation":[{"name":"ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health  Denver Colorado USA"},{"name":"Department of Internal Medicine University of Colorado School of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Blalock","sequence":"additional","affiliation":[{"name":"Center of Innovation to Accelerate Discovery and Practice Transformation Durham Veterans Affairs Medical Center  Durham North Carolina USA"},{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Foster","sequence":"additional","affiliation":[{"name":"ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-6428","authenticated-orcid":false,"given":"Philip S.","family":"Mehler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Colorado School of Medicine  Denver Colorado USA"},{"name":"Eating Recovery Center and Pathlight Mood and Anxiety Center  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.1998.00381.x"},{"key":"e_1_2_10_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"APA","year":"2013"},{"key":"e_1_2_10_4_1","volume-title":"Practice Guidelines for the Treatment of Patients with Eating Disorders","author":"APA","year":"2023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051396"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10249"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.02.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004033.pub3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038682"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114565245"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098\u2010108X(200011)28:3<284::AID\u2010EAT5>3.0.CO;2\u2010G"},{"key":"e_1_2_10_12_1","first-page":"73","volume-title":"Diabetes Mellitus: Diagnosis and Treatment","author":"Hamwi G. 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