{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:09:30Z","timestamp":1792606170167,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Binge\u2010Eating Disorder (BED) causes significant psychosocial impairment and comorbidities like obesity, depression, and anxiety. Given the limited effectiveness of current treatments, Lisdexamfetamine dimesylate (LDX), approved for Attention\u2010Deficit\/Hyperactivity Disorder\u2010 ADHD and BED in the U.S., may provide a promising alternative by enhancing impulse control and targeting reward pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to assess the efficacy, safety, and tolerability of LDX compared with placebo in adults with BED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase and Cochrane databates for randomised controlled trials (RCTs). We used a random\u2010effects model with a 95% confidence interval (CI) to pool the data. Outcomes analysed included binge\u2010eating frequency, Yale\u2010Brown Obsessive\u2010Compulsive Scale for Binge\u2010Eating (Y\u2010BOCS\u2010BE), weight change, treatment\u2010emergent adverse events (TEAEs), and discontinuation rates. Sensitivity analyses were performed to assess heterogeneity. This systematic review and meta\u2010analysis was prospectively registered in PROSPERO (CRD42024619617).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five RCTs were included in this meta\u2010analysis, encompassing a total of 988 participants. LDX significantly reduced binge\u2010eating days per week by an average of 1.29\u00a0days and decreased obsessive\u2010compulsive behaviours by 6.16 points on the Y\u2010BOCS\u2010BE scale, compared with placebo. Additionally, LDX led to a significant weight reduction with an average decrease of 1.31 standardised mean differences (SMD). Diarrhoea was identified as a significant side effect not previously acknowledged in guidelines (RR\u00a0=\u00a04.06). Discontinuation rates were comparable between LDX and placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDX demonstrates significant efficacy in reducing binge\u2010eating behaviours and associated obsessive\u2010compulsive symptoms in patients with BED, with a tolerable safety profile. These findings support the clinical use of LDX for managing BED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70070","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:40:33Z","timestamp":1766378433000},"page":"770-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy, Safety and Tolerability of Lisdexamfetamine Dimesylate Treatment Compared With Placebo in Adults With Binge\u2010Eating Disorder: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8823-2588","authenticated-orcid":false,"given":"Maur\u00edcio Pr\u00e4tzel","family":"Ellwanger","sequence":"first","affiliation":[{"name":"Universidade do Contestado  Mafra Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Westphalen","family":"Pomianoski","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8853-0709","authenticated-orcid":false,"given":"Daniela Lopes","family":"Vieira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1115-6377","authenticated-orcid":false,"given":"Manuela Pozza","family":"Ellwanger","sequence":"additional","affiliation":[{"name":"Universidade do Contestado  Mafra Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8913-6437","authenticated-orcid":false,"given":"V\u00edrgilio","family":"Astori","sequence":"additional","affiliation":[{"name":"Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria  Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus Frizzo","family":"Messinger","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890424865"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12639"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000449"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.06.068"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s109637"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000702"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010024\u201001041\u20109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2547"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2428371"},{"key":"e_1_2_11_11_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. P. T.","year":"2020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2023.2179663"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1889"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s68393"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2162"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.275"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205952"},{"key":"e_1_2_11_19_1","volume-title":"RStudio: Integrated Development Environment for R [Internet]","author":"Posit team","year":"2024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000392\u20102"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.03.014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010021\u201001228\u20107"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/erv.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:49:08Z","timestamp":1775245748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,21]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/erv.70070"],"URL":"https:\/\/doi.org\/10.1002\/erv.70070","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,21]]},"assertion":[{"value":"2025-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}