{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:07:46Z","timestamp":1792706866794,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH079978"],"award-info":[{"award-number":["R01MH079978"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH079979"],"award-info":[{"award-number":["R01MH079979"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Executive function deficits are well documented in anorexia nervosa and relate to poorer treatment outcomes, but their clinical relevance in bulimia nervosa (BN) is less clear. This study investigated associations between neurocognition and treatment outcomes in adolescents with BN using complementary hypothesis\u2010driven and data\u2010driven approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adolescents with BN (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a082) enrolled in a randomised controlled treatment trial completed the Delis\u2013Kaplan Executive Functioning System (D\u2010KEFS) and the Eating Disorder Examination (EDE). A priori executive functions investigated included cognitive flexibility, inhibition, problem\u2010solving, and planning.\n                      <jats:italic>K<\/jats:italic>\n                      \u2010means clustering derived neurocognitive profiles based on D\u2010KEFS performance. Multilevel models examined whether a priori executive functions and cluster membership predicted trajectories of EDE Global Scores, objective binge\u2010eating, and self\u2010induced vomiting episodes from baseline to end\u2010of\u2010treatment and 6\u2010 and 12\u2010month follow\u2010ups, controlling for treatment condition (i.e., family\u2010based treatment [FBT] versus cognitive behavioural therapy [CBT]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      None of the a priori executive function indices predicted any outcome (all\n                      <jats:italic>p<\/jats:italic>\n                      s\u00a0&gt;\u00a00.050).\n                      <jats:italic>K<\/jats:italic>\n                      \u2010means clustering identified two distinct neurocognitive profiles. Relative to Cluster 1 (high\u2010average D\u2010KEFS performance), individuals in Cluster 2 (low\u2010average D\u2010KEFS performance) exhibited a significantly higher frequency of self\u2010induced vomiting across post\u2010treatment timepoints (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Findings suggest that neurocognitive profiles may be more informative for predicting psychopathology in adolescent BN than individual executive function measures. Better overall performance on the D\u2010KEFS may confer protection against higher purging frequency across time. Identifying neurocognitive profiles at intake may help identify adolescents at risk for elevated purging over time and inform tailored interventions to support treatment outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70128","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:24:43Z","timestamp":1778786683000},"page":"1384-1394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurocognitive Profiles and Predictors of Symptom Trajectory During and After Treatment in Adolescent Bulimia Nervosa"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-2924","authenticated-orcid":false,"given":"Simar","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-7817","authenticated-orcid":false,"given":"Franziska","family":"Plessow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-0747","authenticated-orcid":false,"given":"Erin E.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Gorrell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany E.","family":"Matheson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Lock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-9496","authenticated-orcid":false,"given":"Daniel","family":"Le Grange","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience The University of Chicago (Emeritus)  Chicago Illinois USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California, (Emeritus)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.02.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1809"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22340"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/t15082\u2010000"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195134971.003.0029"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.115717"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr120"},{"key":"e_1_2_11_9_1","first-page":"1","article-title":"The Eating Disorder Examination","volume":"6","author":"Fairburn C. 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