{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:48:25Z","timestamp":1791809305942,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24MH135189"],"award-info":[{"award-number":["K24MH135189"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Many patients with larger bodies present to eating disorder (ED) treatment seeking weight loss. Whether glucose\u2010dependent insulinotropic polypeptide\/glucagon\u2010like\u2010peptide receptor agonists (GIP\/GLP\u20101s) are helpful or harmful for such patients remains unknown. This single case experimental design study examined the effects of Tirzepatide (7.5\u00a0mg\/0.05\u00a0mL), a GIP\/GLP\u20101 following 10\u2010session cognitive\u2010behavioural therapy (CBT\u2010T) in a patient with binge\u2010eating disorder (BED) and obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A 37\u2010year\u2010old female presented to an outpatient ED clinic with BED and a body mass index of 68.9\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . We assessed weekly and then monthly ED behaviours and cognitions using the Eating Disorder 15 (ED\u201015) across two treatment phases: CBT\u2010T (3\u00a0months) and GIP\/GLP\u20101 administration (9\u00a0months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As hypothesised, ED cognitions and binge frequency decreased during CBT\u2010T. Also as hypothesised, during GIP\/GLP\u20101 phase, binge frequency remained low and dietary restraint absent. We observed continued reductions in ED cognitions and 39\u2010pound weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>GIP\/GLP\u20101 treatment after CBT\u2010T was followed by ED remission and weight loss without serious adverse events. CBT\u2010T skills may mitigate risk of disordered eating during GIP\/GLP\u20101 use. The combination of psychotherapy and GIP\/GLP\u20101s may further reduce binge\u2010eating and lead to weight loss. Research is needed to explore risks and benefits of GIP\/GLP\u20101s for patients\u00a0with EDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70135","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T18:44:27Z","timestamp":1780771467000},"page":"1465-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucose\u2010Dependent Insulinotropic Polypeptide\/Glucagon\u2010Like\u2010Peptide\u20101 Use Following 10\u2010Session Cognitive\u2013Behavioural Therapy for Binge\u2010Eating Disorder: A Single\u2010Case Experimental Design"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-6437","authenticated-orcid":false,"given":"Ashley","family":"Dunford","sequence":"first","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5887-5985","authenticated-orcid":false,"given":"Stefania","family":"Yee","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-581X","authenticated-orcid":false,"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-0930","authenticated-orcid":false,"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4441-8381","authenticated-orcid":false,"given":"Esther","family":"Dechant","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12010147"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10640266.2024.2421057"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22887"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23297"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24429"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13284207.2022.2075257"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24483"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010025\u201001720\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010022\u201000622\u2010w"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22430"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/320803"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2025.89778"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780367192280"}],"container-title":["European 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