{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:06:34Z","timestamp":1789020394408,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R00MH132886"],"award-info":[{"award-number":["R00MH132886"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["31876"],"award-info":[{"award-number":["31876"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Individuals with anorexia nervosa (AN) share premorbid traits with Parkinson's Disease (PD) (e.g.,\u00a0anxiety) and exhibit a two\u2010fold relative risk of a reported family history of PD. Published estimates of intra\u2010 and inter\u2010disorder genetic architecture were extracted and compared prior to conducting novel analyses to provide evidence for cross\u2010disorder genetic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>National register or meta\u2010analytic familial, twin, and common variant genome\u2010wide studies were searched; estimates and findings were extracted and compared. Novel cross\u2010disorder conditional and conjunctional false discovery rate analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sibling relative risks and additive genetic estimates of the two disorders were similar. AN had greater common variant heritability than PD whether measured via infinitesimal model (linkage disequilibrium score regression, LDSC) or causal mixture model (MiXeR). AN had greater polygenicity than PD (mean (SD) 2.50E\u201003 (1.64E\u201004) versus 2.72E\u20104 (1.47E\u201005),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), but lower discoverability than PD (4.20E\u201005 (2.69E\u201006) versus 1.40E\u201004 (6.95E\u201006),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Global genetic correlation was significant (e.g.,\u00a0bivariate LDSC\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>g<\/jats:sub>\n                      \u00a0=\u00a00.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0033). Novel analyses identified cross\u2010disorder enrichment, and cross\u2010disorder risk at chr3p21.31.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cross\u2010disorder AN and PD research identified shared risk variants at chr3p21.31, genes and mechanisms (e.g.,\u00a0conditioning, fear, and reward) linked to a shared endophenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70158","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:16:30Z","timestamp":1789017390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eating Disorders and Parkinson's Disease\u20142: Genetic Epidemiology and Shared Genomics"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-7644","authenticated-orcid":false,"given":"Andrew 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-4906","authenticated-orcid":false,"given":"Walter H.","family":"Kaye","sequence":"additional","affiliation":[{"name":"University of California San Diego (UCSD)  La Jolla California 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