{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:34Z","timestamp":1788347674058,"version":"build-2803163510"},"reference-count":83,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness\u2010related correlates of AN, and establish a foundation for forthcoming biological, neuroimaging, endocrinological, and microbiota studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MZ twins discordant for lifetime AN (44 individuals) and control MZ twin pairs (42 individuals) were recruited. Analyses included total\u2010sample associations with AN, between\u2010group comparisons (affected, unaffected co\u2010twins, controls), and within\u2010pair analyses of discordant twins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Affected twins, most of whom were weight\u2010restored and non\u2010acute, differed markedly from unaffected co\u2010twins and controls. Lifetime AN was associated with higher perfectionism, goal\u2010directed drive, neuroticism, behavioural inhibition, impulsivity, broader psychiatric symptoms, teasing history, autism symptoms, and lower quality of life. Within\u2010pair analyses implicated perfectionism, goal\u2010directed drive, and competency\u2010related teasing as candidate individual\u2010specific risk factors for AN, with evidence of additional associations with impulsivity, behavioural inhibition, neuroticism, broader psychiatric symptoms, and autism symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings support a multifactorial model of AN involving individual\u2010specific influences and shared familial liability. Perfectionism, goal\u2010directed drive, and competency\u2010related teasing emerged as candidate individual\u2010specific risk factors, while the pattern of elevations, with unaffected co\u2010twins often falling between affected twins and healthy controls, suggests that several clinical and phenotypic features may reflect familial liability for AN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70165","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:28:21Z","timestamp":1788344901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-381X","authenticated-orcid":false,"given":"Hunna 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