{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:15:46Z","timestamp":1788437746987,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic malnutrition, hypothermia, and hormonal imbalance in anorexia nervosa (AN) may impair capillary structure and perfusion. This study aimed to describe the nailfold videocapillaroscopy (NVC) findings in adolescents with AN and atypical AN (AAN), to assess their association with Raynaud's phenomenon (RP), and evaluate longitudinal capillary changes following medical remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the NVC findings of 26 adolescents with AN, 24 with AAN and 9 with primary RP as a control group (12\u201318\u00a0years). Additionally, 23 patients with AN and AAN were reevaluated after achieving medical remission and weight restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While both the AN and AAN group had significant capillary changes, most NVC parameters were comparable between the groups, except for a higher prevalence of early scleroderma pattern in AN (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.037). RP was associated with higher enlarged capillary scores in AN (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018) and higher prevalence of early scleroderma pattern in AAN (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007). Univariate analysis showed vital instability significantly heightened odds of having hemorrhages (OR\u00a0=\u00a05.79), giant capillaries (OR\u00a0=\u00a03.93) and tortuosity (OR\u00a0=\u00a03.82). Longitudinal assessment showed improvement in almost all capillary changes, with all early scleroderma patterns completely resolving after medical remission (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest the presence of microvascular alterations in adolescents with AN, particularly during the acute phase. Although weight restoration improved microvascular changes, long\u2010term monitoring is necessary to determine whether all findings resolve over time or there is an increased risk of developing sequelae in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70167","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:33:39Z","timestamp":1788435219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microvascular Abnormalities in Adolescents With Anorexia Nervosa: Nailfold Video Capillaroscopic Evidence at Acute and Remission States"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-8894","authenticated-orcid":false,"given":"Muserref","family":"Kasap\u2010Cuceoglu","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-050X","authenticated-orcid":false,"given":"Melis","family":"Pehlivanturk\u2010Kizilkan","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Sag","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-8996","authenticated-orcid":false,"given":"Seher","family":"Sener","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Balik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Akgul","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Derman","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-7926","authenticated-orcid":false,"given":"Nuray","family":"Kanbur","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine Universirty of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-7868","authenticated-orcid":false,"given":"Seza","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hacettepe University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2020.1780310"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12081196"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf544"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u20105\u00ae)","author":"American Psychological Association","year":"2013"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40505"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.67.783.33"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.01.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh156"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-1-4419-5774-0_27","volume-title":"Scleroderma: From Pathogenesis to Comprehensive Management","author":"Cutolo M.","year":"2012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2019.1614915"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"155","article-title":"Nailfold Videocapillaroscopy Assessment of Microvascular Damage in Systemic Sclerosis","volume":"27","author":"Cutolo M.","year":"2000","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/784947"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.03.004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1417828"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae296"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00438"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222658699"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010022\u201000724\u20105"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/6019.3454"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24172"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20503"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10040697"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2397198319826467"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.101474"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.06.003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.10.008"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010017\u20103808\u20100"},{"issue":"6","key":"e_1_2_12_29_1","first-page":"905","article-title":"Capillaroscopic Observations in Childhood Rheumatic Diseases and Healthy Controls","volume":"23","author":"Ingegnoli F.","year":"2005","journal-title":"Clinical & Experimental Rheumatology"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24298"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.682208"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103999(03)00381\u20107"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121914"},{"issue":"34","key":"e_1_2_12_34_1","first-page":"1850","article-title":"[Digital necrosis in a Patient With Anorexia Nervosa. Association of Vasculopathy and Radial Artery Injury]","volume":"29","author":"Launay D.","year":"2000","journal-title":"Presse Medicale"},{"issue":"4","key":"e_1_2_12_35_1","first-page":"138","article-title":"The Use of Hand Perfusion Scintigraphy to Assess Raynaud\u2019s Phenomenon Associated With Hand\u2010Arm Vibration Syndrome","volume":"35","author":"Lee K.\u2010A.","year":"2017","journal-title":"Clinical & Experimental Rheumatology"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0610559"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.020"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2022.08.006"},{"issue":"1","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2024-eular.4865","article-title":"AB1496 Microcirculation Characterization in Anorexia Nervosa Patients With Raynaud\u2019s Phenomenon","volume":"83","author":"Natalello G.","year":"2024","journal-title":"Annals of the Rheumatic Diseases"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21681"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104845"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22481"},{"key":"e_1_2_12_43_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2021.649848","article-title":"Autonomic Nervous\u00a0System Response to Psychosocial Stress in Anorexia Nervosa: A Cross\u2010Sectional and Controlled Study","volume":"12","author":"Schmalbach I.","year":"2021","journal-title":"Frontiers in Psychology"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqad079"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22095043"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13953"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev441"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102458"},{"issue":"1","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2023.101849","article-title":"Nailfold Capillaroscopy","volume":"37","author":"Smith V.","year":"2023","journal-title":"Best Practice & Research Clinical Rheumatology"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010023\u201002521\u20105"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2023.03.005"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.11.011"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079756"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/974530"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjpediatr.2025.6241"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12454"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.43"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1507638"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2025.104796"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20418"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2019.03.004"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.70167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/erv.70167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.70167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:33:42Z","timestamp":1788435222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.70167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":60,"alternative-id":["10.1002\/erv.70167"],"URL":"https:\/\/doi.org\/10.1002\/erv.70167","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"2025-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"erv.70167"}}