{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:48:25Z","timestamp":1791787705491,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Avoidant\/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a complex paediatric feeding and eating disorder associated with significant medical and psychiatric burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This systematic review and meta\u2010analysis followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251241490). PsycINFO, PubMed, Scopus, and Web of Science were searched. Observational and clinical studies reporting medical and\/or psychiatric comorbidities in paediatric ARFID samples were included. Random\u2010effects models generated pooled prevalence estimates; heterogeneity, publication bias, and evidence certainty were evaluated using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      , Egger's test, and GRADE, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010four studies met inclusion criteria. Gastrointestinal disorders (30%; 95% CI: 21%\u201342%) and nutritional deficiencies (32%; 95% CI: 23%\u201342%) were the most prevalent medical comorbidities. Food allergies were present in 15% (95% CI: 9%\u201323%). Among psychiatric conditions, anxiety disorders were most common (44%; 95% CI: 39%\u201349%), followed by depression (18%; 95% CI: 15%\u201321%), autism spectrum disorder (19%; 95% CI: 15%\u201324%), attention\u2010deficit\/hyperactivity disorder (15%; 95% CI: 13%\u201318%), and obsessive\u2013compulsive disorder (11%; 95% CI: 9%\u201313%). Heterogeneity was high across outcomes (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0\u2265\u00a075%). Publication bias was detected for anxiety, depression, and nutritional deficiencies. Overall certainty of evidence ranged from very low to low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Paediatric ARFID is associated with substantial medical and psychiatric comorbidity, particularly anxiety and neurodevelopmental conditions. Findings support comprehensive, multidisciplinary assessment and developmentally informed interventions. Further high\u2010quality, population\u2010based studies are needed to reduce heterogeneity and strengthen evidence certainty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70172","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:32Z","timestamp":1791181532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Medical and Psychiatric Comorbidities in Paediatric ARFID: A Meta\u2010Analysis"],"prefix":"10.1002","author":[{"given":"Nuria Blay","family":"Borch","sequence":"first","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2322-0629","authenticated-orcid":false,"given":"Patricia Sanazario","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rut Vila","family":"del Pozo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1346-5996","authenticated-orcid":false,"given":"Juan David","family":"Duque\u2010Yemail","sequence":"additional","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation  Barcelona Spain"},{"name":"Hospital San Rafael. Hermanas Hospitalarias  Barcelona Spain"},{"name":"Department of Psychiatry and Legal Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-1717","authenticated-orcid":false,"given":"Laura","family":"Gisbert\u2010Gustemps","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia Spain"},{"name":"Department of Psychiatry and Legal Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental Instituto de Salud Carlos III  Madrid Spain"},{"name":"Psychiatric Genetics Unit Vall d\u2019Hebron Research Institute (VHIR)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanol","family":"Seti\u00e9n\u2010Ramos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-4011","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mart\u00ednez\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental Instituto de Salud Carlos III  Madrid Spain"},{"name":"Psychiatric Genetics Unit Vall d\u2019Hebron Research Institute (VHIR)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-0350","authenticated-orcid":false,"given":"Josep Antoni","family":"Ramos\u2010Quiroga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital Universitari Vall d\u2019Hebron  Barcelona Catalonia 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Health Organization.2019.International Statistical Classification of Diseases and Related Health Problems (ICD\u201011).11th ed.https:\/\/icd.who.int\/."}],"container-title":["European Eating Disorders 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