{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:47:37Z","timestamp":1792061257544,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro Eating Disorders Rev"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate lifetime cost\u2013utility of an integrated enhanced cognitive behavioural therapy (CBT\u2010E) inpatient\u2013day patient pathway versus prolonged inpatient treatment\u2010as\u2010usual (TAU) for treatment\u2010experienced adults with anorexia nervosa requiring intensive specialist treatment in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A five\u2010state cohort Markov model estimated societal costs and quality\u2010adjusted life years (QALYs) over a lifetime horizon using published clinical and UK economic inputs. Deterministic and probabilistic sensitivity analyses examined parameter uncertainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The integrated pathway was associated with 23.30 modelled QALYs and costs of \u00a3234,379.69, compared with 18.64 QALYs and \u00a3831,105.70 for TAU: an incremental gain of 4.65 QALYs and savings of approximately \u00a3596,726. Findings were most sensitive to treatment responsiveness, relapse, readmission, and chronic disease costs. Probabilistic analyses were broadly consistent with the base\u2010case findings under the specified assumptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These pathway\u2010level, model\u2010based estimates suggest potential health and economic benefits for this intensive\u2010care population. They depend on assumptions about relapse, recovery, and long\u2010term service use and do not isolate the effect of CBT\u2010E psychotherapy. Findings can inform research and service planning. Prospective comparative economic evaluation remains necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/erv.70178","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:12:08Z","timestamp":1792059128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2013Utility Analysis of an Integrated CBT\u2010E Inpatient\u2013Day Patient Treatment Pathway for Treatment\u2010Experienced Anorexia Nervosa in the United Kingdom"],"prefix":"10.1002","author":[{"given":"Anchith","family":"Kota","sequence":"first","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-7854","authenticated-orcid":false,"given":"Diego","family":"Manriquez\u2010Robles","sequence":"additional","affiliation":[{"name":"Departamento de Psicolog\u00eda Universidad de La Frontera  Temuco Chile"},{"name":"Department of Psychological Sciences Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-9432","authenticated-orcid":false,"given":"Andres","family":"Roman\u2010Urrestarazu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Department of International Health Maastricht University  Maastricht the Netherlands"},{"name":"Departamento de Psiquiatr\u00eda Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010016\u20100264\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425787","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjb.2021.73"},{"key":"e_1_2_11_6_1","volume-title":"The Costs of Eating Disorders: Social, Health and Economic Impacts","author":"Beat","year":"2015"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000453"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22715"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010021\u201000433\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2016.11.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102645"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350058"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732314524029"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08040608"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005\u20107967(02)00088\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24113"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2822"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00757\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010021\u201000499\u20101"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/23814683211061097"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010022\u201000620\u2010y"},{"key":"e_1_2_11_23_1","volume-title":"Global Burden of Disease","author":"Institute for Health Metrics and Evaluation","year":"2026"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010022\u201006386\u20107"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010024\u201001082\u20100"},{"key":"e_1_2_11_26_1","volume-title":"Unit Costs of Health and Social Care 2024 Manual","author":"Jones K. 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