{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:50:50Z","timestamp":1772304650257,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T00:00:00Z","timestamp":1342828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of humic acids, over a concentration range of 0 to 20\u2009mg\u2009L\u22121, was investigated in the uptake of three metals (Cd, Cr, and Hg\u2014as both inorganic Hg [Hg(II)] and methylmercury [MeHg]) and a metalloid (As) from the aqueous phase by the killifish (Fundulus heteroclitus). Cadmium uptake showed no relationship with humic acid concentration, whereas Cr, Hg(II), and MeHg uptake showed an inverse relationship, and As uptake increased with increasing humic acid concentration. Concentration factors were &amp;gt;1 for Cd, Hg(II), and MeHg at all humic acid concentrations, indicating killifish were more enriched in the metal than the experimental media, whereas As and Cr generally had concentration factors &amp;lt;1 at the end of a 72-h exposure. The uptake of As and Cr reached steady state within the 72-h exposure, whereas uptake of Cd, Hg(II), and MeHg did not. Uptake rate constants (kus;\u2009ml\u2009g\u22121\u2009d\u22121) were highest for MeHg (91\u20133,936), followed by Hg(II), Cd, and Cr, and lowest for As (0.17\u20130.29). Dissection data revealed that the gills generally had the highest concentration of all metals under all humic acid treatments. The present study concludes that changes in humic acid concentration can influence the accumulation of aqueous metals in killifish and should be considered when modeling metal bioaccumulation. Environ. Toxicol. Chem. 2012; 31: 2225\u20132232. \u00a9 2012 SETAC<\/jats:p>","DOI":"10.1002\/etc.1947","type":"journal-article","created":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T04:05:23Z","timestamp":1342929923000},"page":"2225-2232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Influence of humic acid on the uptake of aqueous metals by the killifish <i>Fundulus heteroclitus<\/i>"],"prefix":"10.1093","volume":"31","author":[{"given":"Jessica","family":"Dutton","sequence":"first","affiliation":[{"name":"Environmental Studies Program, Adelphi University, Garden City, NY."},{"name":"School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,7,21]]},"reference":[{"key":"2025010313582877300_bib1","first-page":"45","volume-title":"Metal Speciation and Bioavailability in Aquatic Systems","author":"Campbell","year":"1995"},{"key":"2025010313582877300_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1139\/f98-187","article-title":"Natural and commercial dissolved organic matter protects against the physiological effects of a combined cadmium and copper exposure on rainbow trout (Oncorhynchus mykiss)","volume":"56","author":"Richards","year":"1999","journal-title":"Can J Fish Aquat Sci"},{"key":"2025010313582877300_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4319\/lo.1978.23.5.0870","article-title":"Effects of complexation by natural organic ligands on the toxicity of copper to a unicellular alga, Monochrysis lutheri","volume":"23","author":"Sunda","year":"1978","journal-title":"Limnol Oceanogr"},{"key":"2025010313582877300_bib4","first-page":"363","volume-title":"Metal Speciation and Bioavailability in Aquatic Systems","author":"Fisher","year":"1995"},{"key":"2025010313582877300_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/35024069","article-title":"Uptake of dissolved organic carbon and trace elements by zebra mussels","volume":"407","author":"Roditi","year":"2000","journal-title":"Nature"},{"key":"2025010313582877300_bib6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/es001758l","article-title":"Effect of dissolved organic matter on the uptake of trace metals by American oysters","volume":"35","author":"Guo","year":"2001","journal-title":"Environ Sci Technol"},{"key":"2025010313582877300_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.envpol.2003.11.015","article-title":"Influences of dissolved and colloidal organic carbon on the uptake of Ag, Cd, and Cr by the marine mussel Perna viridis","volume":"129","author":"Pan","year":"2004","journal-title":"Environ Pollut"},{"key":"2025010313582877300_bib8","first-page":"340","article-title":"Toxicity of dissolved Cu, Zn, Ni and Cd to developing embryos of the blue mussel (Mytilus trossolus) and the protective effect of dissolved organic carbon","volume":"149","author":"Nadella","year":"2009","journal-title":"Comp Biochem Physiol C"},{"key":"2025010313582877300_bib9","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/etc.5620201034","article-title":"Biotic ligand model of the acute toxicity of metals. 1. 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