{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:51:50Z","timestamp":1792068710861,"version":"4.4.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:00:00Z","timestamp":1376438400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Vertebrate testing under the European Union's regulation on Registration, Evaluation, Authorisation and Restriction of Chemical substances (REACH) is discouraged, and the use of alternative nontesting approaches such as quantitative structure\u2013activity relationships (QSARs) is encouraged. However, robust QSARs predicting chronic ecotoxicity of organic compounds to fish are not available. The Ecological Structure Activity Relationships (ECOSAR) Class Program is a computerized predictive system that estimates the acute and chronic toxicity of organic compounds for several chemical classes based on their log octanol\u2013water partition coefficient (KOW). For those chemical classes for which chronic training data sets are lacking, acute to chronic ratios are used to predict chronic toxicity to aquatic organisms. Although ECOSAR reaches a high score against the Organisation for Economic Co-operation and Development (OECD) principles for QSAR validation, the chronic QSARs in ECOSAR are not fully compliant with OECD criteria in the framework of REACH or CLP (classification, labeling, and packaging) regulation. The objective of the present study was to develop a chronic ecotoxicity QSAR for fish for compounds acting via nonpolar and polar narcosis. These QSARs were built using a database of quality screened toxicity values, considering only chronic exposure durations and relevant end points. After statistical multivariate diagnostic analysis, literature-based, mechanistically relevant descriptors were selected to develop a multivariate regression model. Finally, these QSARs were tested for their acceptance for regulatory purposes and were found to be compliant with the OECD principles for the validation of a QSAR. Environ Toxicol Chem 2013;32:2217\u20132225. \u00a9 2013 SETAC<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/etc.2301","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T05:59:24Z","timestamp":1371535164000},"page":"2217-2225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Development and validation of a quantitative structure\u2013activity relationship for chronic narcosis to fish"],"prefix":"10.1093","volume":"32","author":[{"given":"Lieve","family":"Claeys","sequence":"first","affiliation":[{"name":"ARCHE, , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Iaccino","sequence":"additional","affiliation":[{"name":"ARCHE, , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Toxicology and Aquatic EcologyGhent University, , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Van Sprang","sequence":"additional","affiliation":[{"name":"ARCHE, , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Verdonck","sequence":"additional","affiliation":[{"name":"ARCHE, , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"2025010314200522100_etc2301-bib-0001","author":"Dearden","year":"2007"},{"key":"2025010314200522100_etc2301-bib-0002","first-page":"374","article-title":"Regulation (EC) 1907\/2006 of the European Parliament and of the Council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999\/45\/EC and repealing Council Regulation (EEC) 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