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Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia. In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants. Environ Toxicol Chem 2013;32:2866\u20132869. \u00a9 2013 SETAC<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/etc.2378","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T06:49:18Z","timestamp":1378104558000},"page":"2866-2869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Acute and chronic effects of diphenhydramine and sertraline mixtures in\n                    <i>Ceriodaphnia dubia<\/i>"],"prefix":"10.1093","volume":"32","author":[{"given":"Eric W.","family":"Goolsby","sequence":"first","affiliation":[{"name":"Department of Environmental Health ScienceUniversity of Georgia, , Athens, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase M.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Plant BiologyUniversity of Georgia, , Athens, Georgia , 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