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In the present study, 4-month-old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27\u2009\u00b5g\/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. The PCP exposure at 27\u2009\u00b5g\/L resulted in elevated plasma thyroxine concentrations in male and female zebrafish and depressed 3, 5, 3'-triiodothyronine concentrations in males only. In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid-stimulating hormone \u03b2-subunit (tsh\u03b2) and thyroid hormone receptor \u03b2 (tr\u03b2) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1). The authors also identified several sex-specific effects of PCP exposure, including changes in mRNA levels for deiodinase 2 (dio2), cytosolic sulfotransferase (sult1 st5), and transthyretin (ttr) genes in the liver. Environmental PCP exposure also caused an increased malformation rate in offspring that received maternal exposure to PCP. The present study demonstrates that chronic exposure to environmental levels of PCP alters plasma thyroid hormone levels, as well as the expression of genes associated with thyroid hormone signaling and metabolism in the hypothalamic-pituitary-thyroid (HPT) axis and liver, resulting in abnormal zebrafish development. Environ Toxicol Chem 2014;33:170\u2013176. \u00a9 2013 SETAC<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/etc.2408","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:40:28Z","timestamp":1381527628000},"page":"170-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish"],"prefix":"10.1093","volume":"33","author":[{"given":"Li-Qin","family":"Yu","sequence":"first","affiliation":[{"name":"China Institute of Water Resources and Hydropower Research Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Feng","family":"Zhao","sequence":"additional","affiliation":[{"name":"China Institute of Water Resources and Hydropower Research Beijing 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