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High-throughput live cell arrays provide a promising method for the characterization of the effects of chemicals and the associated molecular mechanisms. In the present study, this test system was evaluated for the first time for the characterization of a set of typical surface water extracts receiving effluent from WWTPs. The extracts containing complex mixtures of micropollutants were analyzed for the expression of 90 stress responsive genes in the Escherichia coli reporter gene assay. The most affected pathways and the genes most sensitive to surface water samples suggested prominent stress-responsive pathways for wastewater-impacted surface water, such as oxidative stress, DNA damage, and drug resistance. Samples strongly affecting particular pathways were identified by statistical analysis of gene expression. Transcription data were correlated with contamination data from chemical screening and percentages of wastewater in the samples. Samples with particular effects and outstanding chemical composition were analyzed. For these samples, hypotheses on the alteration of the transcription of genes involved in drug resistance and DNA repair attributable to the presence of pharmaceuticals were drawn. Environ Toxicol Chem 2015;34:2523\u20132532. \u00a9 2015 SETAC<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/etc.3083","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T16:23:03Z","timestamp":1432916583000},"page":"2523-2532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Microbial reporter gene assay as a diagnostic and early warning tool for the detection and characterization of toxic pollution in surface waters"],"prefix":"10.1093","volume":"34","author":[{"given":"Christine","family":"Hug","sequence":"first","affiliation":[{"name":"Institute for Environmental Research, Department of Ecosystem AnalysesRWTH Aachen University Aachen Nordrhein-Westfalen Germany"},{"name":"Department of Effect-Directed AnalysisUFZ-Helmholtz Centre for Environmental Research Leipzig Saxony 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for Environmental Research Leipzig Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Effect-Directed AnalysisUFZ-Helmholtz Centre for Environmental Research Leipzig Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Department of Effect-Directed AnalysisUFZ-Helmholtz Centre for Environmental Research Leipzig Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henner","family":"Hollert","sequence":"additional","affiliation":[{"name":"Key Laboratory of Yangtze Water Environment, Ministry of EducationTongji University Shanghai Shanghai People's Republic of China"},{"name":"College of Resources and Environmental ScienceChongqing University Chongqing Chongqing People's Republic of China"},{"name":"State Key Laboratory of Pollution Control & 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