{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:08:24Z","timestamp":1770512904748,"version":"3.49.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IGA VFU 4\/2014\/FVHE"},{"name":"IGA VFU 4\/2014\/FVHE"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The authors performed a toxicity test with ciprofloxacin in fertilized eggs of common carp according to guideline 210 of the Organisation for Economic Co-operation and Development. The tested concentrations were 1\u2009\u03bcg\u2009L\u22121, 100\u2009\u03bcg\u2009L\u22121, 500\u2009\u03bcg\u2009L\u22121, 1000\u2009\u03bcg\u2009L\u22121, and 3000\u2009\u03bcg\u2009L\u22121. Accelerated hatching was found in all groups exposed to ciprofloxacin, but significant growth reduction was found only in the group exposed to the highest concentration (3000\u2009\u03bcg\u2009L\u22121). Increased numbers of macroscopic morphological anomalies were observed on day 6 of the test (after hatching). The highest numbers of macroscopic morphological anomalies were observed in the groups of free embryos and larvae exposed to ciprofloxacin concentrations of 100\u2009\u03bcg\u2009L\u22121, 500\u2009\u03bcg\u2009L\u22121, 1000\u2009\u03bcg\u2009L\u22121, and 3000\u2009\u03bcg\u2009L\u22121 (20\u221223% of tested samples). A gradual decrease in glutathione S-transferase activity was detected in all experimental groups exposed to ciprofloxacin, but significant differences (p\u2009&amp;lt;\u20090.01) were found only in groups treated with 500\u2009\u03bcg\u2009L\u22121 and 3000\u2009\u03bcg\u2009L\u22121. Glutathione peroxidase and catalase exhibited increased activity in most of the tested concentrations (p\u2009&amp;lt;\u20090.01 and &amp;lt;0.05, respectively), whereas decreased glutathione reductase activity was found in the groups exposed to ciprofloxacin concentrations of 500\u2009\u03bcg\u2009L\u22121 and 3000\u2009\u03bcg\u2009L\u22121 (p\u2009&amp;lt;\u20090.05). The concentration of thiobarbituric acid\u2013reactive substances was significantly lower (p\u2009&amp;lt;\u20090.01) in all experimental groups exposed to ciprofloxacin. The lowest-observed-effect concentration of ciprofloxacin was 1\u2009\u03bcg\u2009L\u22121. These results suggest that hatching, early ontogeny, occurrence of morphological anomalies, antioxidant and biotransformation enzyme activity, and lipid peroxidation in fish can be affected by ciprofloxacin. Environ Toxicol Chem 2016;35:1733\u20131740. \u00a9 2015 SETAC<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/etc.3317","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T06:02:08Z","timestamp":1449122528000},"page":"1733-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effects of ciprofloxacin on early life stages of common carp (<i>Cyprinus carpio<\/i>)"],"prefix":"10.1093","volume":"35","author":[{"given":"Dana","family":"Zivna","sequence":"first","affiliation":[{"name":"Department of Veterinary Public Health and Animal WelfareFaculty of Veterinary Hygiene and EcologyUniversity of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Plhalova","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Animal WelfareFaculty of Veterinary 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