{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:12:10Z","timestamp":1790849530314,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Strobilurins constitute a new class of fungicides that is the most widely used in the world. The present study was conducted to investigate the aquatic toxicity of 3 common strobilurin fungicides (kresoxim-methyl, pyraclostrobin, and trifloxystrobin) to Daphnia magna. The neonate acute immobilization test showed that the 48-h 50% effective concentration (EC50) values of kresoxim-methyl, pyraclostrobin, and trifloxystrobin were 443.3\u2009\u00b5g\/L, 20.9\u2009\u00b5g\/L, and 23.0\u2009\u00b5g\/L, respectively. In addition, the 3 strobilurins significantly induced activity of the important detoxification enzyme glutathione S-transferase (GST) in D. magna, and there was a significant positive relationship between GST activity and immobility of D. magna after acute exposure. The 3 strobilurins showed higher toxicity to D. magna embryos, and the 48-h EC50 were 157.3\u2009\u00b5g\/L, 3.9\u2009\u00b5g\/L, and 1.7\u2009\u00b5g\/L for kresoxim-methyl, pyraclostrobin, and trifloxystrobin, respectively. The 21-d chronic test revealed that the strobilurins could also significantly affect the reproduction, development, and growth of D. magna at sublethal concentrations. The lowest-observed-effect concentrations of kresoxim-methyl, pyraclostrobin, and trifloxystrobin for reproduction were 20\u2009\u00b5g\/L, 0.15\u2009\u00b5g\/L, and 0.2 \u00b5g\/L, respectively, which were close to environmental concentrations. The findings indicate that strobilurin fungicides are very toxic to D. magna and they are sufficient to cause harm to D. magna at environmentally relevant concentrations. Environ Toxicol Chem 2017;36:182\u2013189. \u00a9 2016 SETAC<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/etc.3520","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T10:41:11Z","timestamp":1465555271000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Toxicity of three strobilurins (kresoxim-methyl, pyraclostrobin, and trifloxystrobin) on <i>Daphnia magna<\/i>"],"prefix":"10.1093","volume":"36","author":[{"given":"Feng","family":"Cui","sequence":"first","affiliation":[{"name":"College of SciencesChina Agricultural University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chai","sequence":"additional","affiliation":[{"name":"College of SciencesChina Agricultural University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of SciencesChina Agricultural University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengju","family":"Wang","sequence":"additional","affiliation":[{"name":"College of SciencesChina Agricultural University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"2025010314594575800_etc3520-bib-0001","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1021\/es506007q","article-title":"Daphnid life cycle responses to the insecticide chlorantraniliprole and its transformation products","volume":"49","author":"Vesna","year":"2015","journal-title":"Environ Sci 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