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The present study investigated protein oxidation in mangrove oysters (Crassostrea brasiliana) exposed to seawater from Balne\u00e1rio Cambori\u00fa, an important tourist destination in Brazil that is affected by urban sewage. Oysters were exposed for 24\u2009h to seawater collected close to the Cambori\u00fa River (CAM1) or 1\u2009km away (CAM2). Seawater from an aquaculture laboratory was used as a reference. Local sewage input was marked by higher levels of coliforms, nitrogen, and phosphorus in seawater, as well as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), linear alkylbenzenes (LABs), and fecal steroid in sediments at CAM1. Exposure of oysters to CAM1 caused marked bioaccumulation of LABs and decreased PAH and PCB concentrations after exposure to both CAM1 and CAM2. Protein thiol oxidation in gills, digestive gland, and hemolymph was evaluated. Lower levels of reduced protein thiols were detected in hemolymph from CAM1, and actin, segon, and dominin were identified as targets of protein thiol oxidation. Dominin susceptibility to oxidation was confirmed in vitro by exposure to peroxides and hypochlorous acid, and 2 cysteine residues were identified as potential sites of oxidation. Overall, these data indicate that urban sewage contamination in local waters has a toxic potential and that protein thiol oxidation in hemolymph could be a useful biomarker of oxidative stress in bivalves exposed to contaminants. Environ Toxicol Chem 2017;36:1833\u20131845. \u00a9 2016 SETAC<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/etc.3543","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T11:20:01Z","timestamp":1467372001000},"page":"1833-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thiol oxidation of hemolymph proteins in oysters <i>Crassostrea brasiliana<\/i> as markers of oxidative damage induced by urban sewage exposure"],"prefix":"10.1093","volume":"36","author":[{"given":"Rafael","family":"Trevisan","sequence":"first","affiliation":[{"name":"Department of Aquaculture Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Flores-Nunes","sequence":"additional","affiliation":[{"name":"Department of Aquaculture Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euler S.","family":"Dolores","sequence":"additional","affiliation":[{"name":"Department of Aquaculture Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jac\u00f3 J.","family":"Mattos","sequence":"additional","affiliation":[{"name":"Department of Aquaculture Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clei E.","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvio T.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Oceanographic Institute University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satie","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Oceanographic Institute University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda C.","family":"Montone","sequence":"additional","affiliation":[{"name":"Oceanographic Institute University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia C.","family":"B\u00edcego","sequence":"additional","affiliation":[{"name":"Oceanographic Institute University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis M. 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