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Because collembolans have a high content of chitin, a new methodology was developed in which the heads of the collembolans were separated from the rest of the body, allowing the hemolymph to leak out. This procedure allows the cells to be released, and after lysis the genetic material is available for the comet assay. Among other key procedures, the use of 30 organisms (20- to 22-d-old adults) per replicate and the correct amount of cells with genetic material (translated as 10\u2009\u03bcL of suspension) applied on the agarose gel were determinants for the success of the results obtained. The methodology was validated by exposing F. candida to a representative metallic element (cadmium) and a representative of organophosphates, the insecticide dimethoate, for a shorter time period of 10 d, compared with the 28 d for the International Organization for Standardization 11267 method. Within this method, the relatively low percentage of DNA damage (30%) observed in controls and the significant increase in terms of percentage of DNA damage for almost all the concentrations of dimethoate and Cd (reaching 52% and 56% of damage in the highest concentrations, respectively) confirmed the genotoxic effect of both compounds and validated this technique. The comet assay proved to be a sensitive technique to detect DNA strand breaks in collembolans\u2019 cells. Environ Toxicol Chem 2017;36:2514\u20132520. \u00a9 2017 SETAC<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/etc.3795","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T12:17:33Z","timestamp":1489666653000},"page":"2514-2520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The comet assay in\n                    <i>Folsomia candida<\/i>\n                    : A suitable approach to assess genotoxicity in collembolans"],"prefix":"10.1093","volume":"36","author":[{"given":"Diogo N.","family":"Cardoso","sequence":"first","affiliation":[{"name":"Department of Biology & Centre for Environmental and Marine Studies (CESAM)University of Aveiro Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biology & Centre for Environmental and Marine Studies 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