{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:33:14Z","timestamp":1790361194680,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201969"],"award-info":[{"award-number":["31201969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41476096"],"award-info":[{"award-number":["41476096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"Postdoctoral Science Foundation of China","doi-asserted-by":"publisher","award":["2012M521275"],"award-info":[{"award-number":["2012M521275"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["JA13424"],"award-info":[{"award-number":["JA13424"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004749","name":"Science and Technology Project of Xiamen","doi-asserted-by":"publisher","award":["3502Z20143027"],"award-info":[{"award-number":["3502Z20143027"]}],"id":[{"id":"10.13039\/501100004749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201969"],"award-info":[{"award-number":["31201969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41476096"],"award-info":[{"award-number":["41476096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2012M521275"],"award-info":[{"award-number":["2012M521275"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["JA13424"],"award-info":[{"award-number":["JA13424"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004749","name":"Xiamen University of Technology","doi-asserted-by":"publisher","award":["3502Z20143027"],"award-info":[{"award-number":["3502Z20143027"]}],"id":[{"id":"10.13039\/501100004749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>\u2003<\/jats:title><jats:p>Oysters accumulate Zn as an adaptation to Zn exposure; however, it is not known whether male and female oysters respond differently to Zn exposure. Proteomic and real-time polymerase chain reaction analyses were used to investigate differential responses of male and female oysters (Crassostrea angulata) to Zn exposure. After exposure to 50\u2009\u03bcg\u2009L\u22121 or 500\u2009\u03bcg\u2009L\u22121 Zn for 30 d, gonads of female oysters accumulated more Zn than those of males, and gonadal development was accelerated in females but was abnormal in males. Differentially expressed proteins after exposure to Zn were identified and shown to function in Zn transport, Ca transport, phosphate metabolism, energy metabolism, immune regulation, oxidative stress responses, gene expression regulation, and fat metabolism. Proteins with functions in Zn transportation and storage, and multifunctional proteins, such as hemicentin-1 and histidinol dehydrogenase, were expressed at significantly higher levels in the gonads of female than male oysters after Zn exposure. Environ Toxicol Chem 2017;36:2602\u20132613. \u00a9 2017 SETAC<\/jats:p><jats:p>Abstract<\/jats:p><jats:p\/><\/jats:sec>","DOI":"10.1002\/etc.3797","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T11:45:10Z","timestamp":1489751110000},"page":"2602-2613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Differential effects of zinc exposure on male and female oysters (<i>Crassostrea angulata<\/i>) as revealed by label-free quantitative proteomics"],"prefix":"10.1093","volume":"36","author":[{"given":"Lianzhong","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Products and Cell EngineeringXiamen Medical College Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life ScienceXiamen University Xiamen People's Republic of China"},{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Life ScienceXiamen University Xiamen People's Republic of China"},{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life ScienceXiamen University Xiamen People's Republic of China"},{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"You","sequence":"additional","affiliation":[{"name":"College of Ocean and Earth SciencesXiamen University Xiamen People's Republic of China"},{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihuan","family":"Ke","sequence":"additional","affiliation":[{"name":"College of Ocean and Earth SciencesXiamen University Xiamen People's Republic of China"},{"name":"State Key Laboratory of Marine Environmental ScienceXiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"2025010315121674500_etc3797-bib-0001","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3945\/an.112.003038","article-title":"Zinc biochemistry: From a single zinc enzyme to a key element of life","volume":"4","author":"Maret","year":"2013","journal-title":"Adv Nutr"},{"key":"2025010315121674500_etc3797-bib-0002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","article-title":"The biochemical basis of zinc physiology","volume":"73","author":"Vallee","year":"1993","journal-title":"Physiol Rev"},{"key":"2025010315121674500_etc3797-bib-0003","first-page":"283","article-title":"The metallobiochemistry of zinc enzymes","volume":"56","author":"Vallee","year":"1984","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"2025010315121674500_etc3797-bib-0004","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: Impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int J Environ Res Public Health"},{"key":"2025010315121674500_etc3797-bib-0005","doi-asserted-by":"crossref","first-page":"1437S","DOI":"10.1093\/jn\/130.5.1437S","article-title":"Function and mechanism of zinc metalloenzymes","volume":"130","author":"McCall","year":"2000","journal-title":"J Nutr"},{"key":"2025010315121674500_etc3797-bib-0006","first-page":"1","article-title":"Copper and zinc, biological role and significance of copper\/zinc imbalance","volume":"3","author":"Osredkar","year":"2011","journal-title":"J Clin Toxicol"},{"key":"2025010315121674500_etc3797-bib-0007","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.envint.2014.12.010","article-title":"Impacts of soil and water pollution on food safety and health risks in China","volume":"77","author":"Lu","year":"2015","journal-title":"Environ Int"},{"key":"2025010315121674500_etc3797-bib-0008","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/ejss.12216","article-title":"Soil, food security and human health: A review","volume":"66","author":"Oliver","year":"2015","journal-title":"Eur J Soil Sci"},{"key":"2025010315121674500_etc3797-bib-0009","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00128-011-0194-2","article-title":"Effects of the metals lead and zinc on the growth, development, and reproduction of Pardosa astrigera (Araneae:Lycosidae)","volume":"86","author":"Chen","year":"2011","journal-title":"Bull Environ Contam Toxicol"},{"key":"2025010315121674500_etc3797-bib-0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0141-1136(94)00004-9","article-title":"Trace metal concentrations in relation to season and gonadal maturation in the oyster Crassostrea iridescens","volume":"40","author":"P\u00e1ez-Osuna","year":"1995","journal-title":"Mar Environ Res"},{"key":"2025010315121674500_etc3797-bib-0011","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00128-011-0417-6","article-title":"Relationship between gonad maturation and heavy metal accumulation in the clam, Galatea paradoxa (Born 1778) from the Volta estuary, Ghana","volume":"87","author":"Adjei-Boateng","year":"2011","journal-title":"Bull Environ Contam Toxicol"},{"key":"2025010315121674500_etc3797-bib-0012","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF01611102","article-title":"Seasonal variation in soft tissue weights and trace metal burdens in the bay mussel, Mytilus edulis","volume":"27","author":"Latouche","year":"1981","journal-title":"Bull Environ Contam Toxicol"},{"key":"2025010315121674500_etc3797-bib-0013","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1139\/f81-004","article-title":"Effects of chronic zinc exposure on the growth, sexual maturity, reproduction, and bioaccumulation of the guppy, Poecilia reticulata","volume":"38","author":"Pierson","year":"1981","journal-title":"Can J Fish Aquat Sci"},{"key":"2025010315121674500_etc3797-bib-0014","volume-title":"Heavy Metals in the Marine Environment","author":"Furness","year":"1990"},{"key":"2025010315121674500_etc3797-bib-0015","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jfca.2005.10.004","article-title":"Trace elements in foods: Zinc contents of raw foods\u2014A comparison of data originating from different geographical regions of the world","volume":"19","author":"Scherz","year":"2006","journal-title":"J Food Compos Anal"},{"key":"2025010315121674500_etc3797-bib-0016","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0025-326X(00)00132-6","article-title":"Zinc in fish, crabs, oysters, and mangrove flora and fauna from Cleveland Bay","volume":"41","author":"Jones","year":"2000","journal-title":"Mar Pollut Bull"},{"key":"2025010315121674500_etc3797-bib-0017","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbrc.2004.08.051","article-title":"Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiae","volume":"323","author":"Devirgiliis","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2025010315121674500_etc3797-bib-0018","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2119\/2007-00037.Sekler","article-title":"Mechanism and regulation of cellular zinc transport","volume":"13","author":"Sekler","year":"2007","journal-title":"Mol Med"},{"key":"2025010315121674500_etc3797-bib-0019","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00424-003-1070-7","article-title":"Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers","volume":"447","author":"Palmiter","year":"2004","journal-title":"Pflugers Arch"},{"key":"2025010315121674500_etc3797-bib-0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00018-014-1746-5","article-title":"Comment on \u201cCurrent understanding of ZIP and ZnT zinc transporters in human health and diseases","volume":"72","author":"Costas","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"2025010315121674500_etc3797-bib-0021","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1074\/jbc.M114.617332","article-title":"Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation","volume":"290","author":"Golan","year":"2015","journal-title":"J Biol Chem"},{"key":"2025010315121674500_etc3797-bib-0022","volume-title":"Biofortification of Food Crops","author":"Kumar","year":"2016"},{"key":"2025010315121674500_etc3797-bib-0023","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.fsi.2014.03.029","article-title":"Metal accumulation and differentially expressed proteins in gill of oyster (Crassostrea hongkongensis) exposed to long-term heavy metal-contaminated estuary","volume":"38","author":"Luo","year":"2014","journal-title":"Fish Shellfish Immun"},{"key":"2025010315121674500_etc3797-bib-0024","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/jn\/126.7.1782","article-title":"Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice","volume":"126","author":"Kelly","year":"1996","journal-title":"J Nutr"},{"key":"2025010315121674500_etc3797-bib-0025","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ecolind.2014.08.041","article-title":"The Lusitanian toadfish as bioindicator of estuarine sediment metal burden: The influence of gender and reproductive metabolism","volume":"48","author":"Pedro","year":"2015","journal-title":"Ecol Indic"},{"key":"2025010315121674500_etc3797-bib-0026","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0043-1354(02)00622-X","article-title":"Natural variation of copper, zinc, cadmium and selenium concentrations in Bembicium nanum and their potential use as a biomonitor of trace metals","volume":"37","author":"Gay","year":"2003","journal-title":"Water Res"},{"key":"2025010315121674500_etc3797-bib-0027","first-page":"29","article-title":"Is gender a factor contributing to the variations in the concentrations of heavy metals (Cd, Cu, Pb and Zn) by the green-lipped mussel Perna viridis","volume":"35","author":"Yap","year":"2006","journal-title":"Ind J Mar Sci"},{"key":"2025010315121674500_etc3797-bib-0028","volume-title":"Metal Contamination in Aquatic Environments: Science and Lateral Management","author":"Luoma","year":"2008"},{"key":"2025010315121674500_etc3797-bib-0029","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/etc.571","article-title":"Copper and zinccontamination in oysters: Subcellular distribution and detoxification","volume":"30","author":"Wang","year":"2011","journal-title":"Environ Toxicol Chem"},{"key":"2025010315121674500_etc3797-bib-0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.aquatox.2013.01.022","article-title":"Inter-site differences of zinc susceptibility of the oyster Crassostrea hongkongensis","volume":"132\u2013133","author":"Liu","year":"2013","journal-title":"Aquat Toxicol"},{"key":"2025010315121674500_etc3797-bib-0031","first-page":"22","article-title":"Zinc causes acute impairment of glutathione metabolism followed by coordinated antioxidant defenses amplification in gills of brown mussels Perna perna","volume":"159","author":"Trevisan","year":"2014","journal-title":"Comp Biochem Physiol C"},{"key":"2025010315121674500_etc3797-bib-0032","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF01685540","article-title":"Acute toxicities of selected heavy metals to the softshell clam Mya arenaria","volume":"17","author":"Eisler","year":"1977","journal-title":"Bull Environ Contam Toxicol"},{"key":"2025010315121674500_etc3797-bib-0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jprot.2013.08.018","article-title":"Proteomic approach for identifying gonad differential proteins in the oyster (Crassostrea angulata) following food-chain contamination with HgCl2","volume":"94","author":"Zhang","year":"2013","journal-title":"J Proteomics"},{"key":"2025010315121674500_etc3797-bib-0034","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1021\/es506330h","article-title":"Speciation of Cu and Zn in two colored oyster species determined by X-ray absorption spectroscopy","volume":"49","author":"Tan","year":"2015","journal-title":"Environ Sci Technol"},{"key":"2025010315121674500_etc3797-bib-0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","article-title":"The oyster genome reveals stress adaptation and complexity of shell formation","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"2025010315121674500_etc3797-bib-0036","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","article-title":"The galvanization of biology: A growing appreciation for the roles of zinc","volume":"271","author":"Berg","year":"1998","journal-title":"Science"},{"key":"2025010315121674500_etc3797-bib-0037","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal"},{"key":"2025010315121674500_etc3797-bib-0038","first-page":"123","article-title":"The role of the cellular antioxidant defense in oxidant carcinogenesis","volume":"102","author":"Cerutti","year":"1994","journal-title":"Environ Health Perspect"},{"key":"2025010315121674500_etc3797-bib-0039","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/j.1460-2075.1995.tb07042.x","article-title":"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc","volume":"14","author":"Palmiter","year":"1995","journal-title":"EMBO J"},{"key":"2025010315121674500_etc3797-bib-0040","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1039\/C4MT00108G","article-title":"ZnT-1 extrudes zinc from mammalian cells functioning as a Zn2+\/H+ exchanger","volume":"6","author":"Shusterman","year":"2014","journal-title":"Metallomics"},{"key":"2025010315121674500_etc3797-bib-0041","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1039\/C5FO00630A","article-title":"Zinc as a micronutrient and its preventive role of oxidative damage in cells","volume":"6","author":"Kloubert","year":"2015","journal-title":"Food Funct"},{"key":"2025010315121674500_etc3797-bib-0042","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.bbrc.2004.08.211","article-title":"A role for ZnT-1 in regulating cellular cation influx","volume":"323","author":"Segal","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2025010315121674500_etc3797-bib-0043","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/biof.1114","article-title":"Zinc signals and immune function","volume":"40","author":"Haase","year":"2013","journal-title":"BioFactors"},{"key":"2025010315121674500_etc3797-bib-0044","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cbic.200800511","article-title":"The metallothionein\/thionein system: An oxidoreductive metabolic zinc link","volume":"10","author":"Bell","year":"2009","journal-title":"Chembiochem"},{"key":"2025010315121674500_etc3797-bib-0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1152\/physrev.1985.65.2.238","article-title":"Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin","volume":"65","author":"Cousins","year":"1985","journal-title":"Physiol Rev"},{"key":"2025010315121674500_etc3797-bib-0046","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1021\/bi5008673","article-title":"The zinc balance: Competitive zinc metalation of carbonic anhydrase and metallothionein 1A","volume":"53","author":"Pinter","year":"2014","journal-title":"Biochemistry"},{"key":"2025010315121674500_etc3797-bib-0047","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbpb.2010.06.006","article-title":"Characterization of the major plasma protein of the eastern oyster, Crassostrea virginica, and a proposed role in host defense","volume":"158","author":"Itoh","year":"2011","journal-title":"Comp Biochem Physiol B"},{"key":"2025010315121674500_etc3797-bib-0048","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/00288330709509898","article-title":"Characterisation of cavortin, the major haemolymph protein of the Pacific oyster (Crassostrea gigas)","volume":"41","author":"Scotti","year":"2007","journal-title":"New Zeal J Mar Freshw Res"},{"key":"2025010315121674500_etc3797-bib-0049","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1128\/JB.184.11.2931-2939.2002","article-title":"An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro","volume":"184","author":"Yamamoto","year":"2002","journal-title":"J Bacteriol"},{"key":"2025010315121674500_etc3797-bib-0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.physiol.68.040104.110001","article-title":"Oxidative stress in marine environments: Biochemistry and physiological ecology","volume":"68","author":"Lesser","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"2025010315121674500_etc3797-bib-0051","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2045-3701-3-27","article-title":"Specific structure and unique function define the hemicentin","volume":"3","author":"Xu","year":"2013","journal-title":"Cell Biosci"},{"key":"2025010315121674500_etc3797-bib-0052","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s12253-014-9809-3","article-title":"HMCN1, a cell polarity-related gene, is somatically mutated in gastric and colorectal cancers","volume":"21","author":"Lee","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"2025010315121674500_etc3797-bib-0053","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1369\/jhc.6A6975.2006","article-title":"Hemicentins assemble on diverse epithelia in the mouse","volume":"55","author":"Xu","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"2025010315121674500_etc3797-bib-0054","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/cvr\/cvu161","article-title":"Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration","volume":"103","author":"Chowdhury","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2025010315121674500_etc3797-bib-0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/13816810590968023","article-title":"HEMICENTIN-1 (FIBULIN-6) and the 1q31 AMD locus in the context of complex disease: Review and perspective","volume":"26","author":"Schultz","year":"2005","journal-title":"Ophthalmic Genet"},{"key":"2025010315121674500_etc3797-bib-0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0135008","article-title":"A label-free proteomic analysis on competent larvae and juveniles of the pacific oyster Crassostrea gigas","volume":"10","author":"Huan","year":"2015","journal-title":"PLoS One"},{"key":"2025010315121674500_etc3797-bib-0057","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1186\/1471-2164-15-951","article-title":"Shotgun proteomics reveals physiological response to ocean acidification in Crassostrea gigas","volume":"15","author":"Timmins-Schiffman","year":"2014","journal-title":"BMC Genomics"},{"key":"2025010315121674500_etc3797-bib-0058","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/oxfordjournals.jbchem.a124298","article-title":"Hisdidinol dehydrogenase loses its catalytic function through the mutation of His261--&gt;Asn due to its inability to ligate the essential Zn","volume":"115","author":"Nagai","year":"1994","journal-title":"J Biochem"},{"key":"2025010315121674500_etc3797-bib-0059","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1073\/pnas.88.10.4133","article-title":"Structural and functional conservation of histidinol dehydrogenase between plants and microbes","volume":"88","author":"Nagai","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025010315121674500_etc3797-bib-0060","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1016\/j.bmcl.2010.04.116","article-title":"Structure based design of novel inhibitors for histodinol dehydrogenase from Geotrichum candidum","volume":"20","author":"Pahwa","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"2025010315121674500_etc3797-bib-0061","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.tcb.2008.04.003","article-title":"HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions","volume":"18","author":"Valenzuela-Fern\u00e1ndez","year":"2008","journal-title":"Trends Cell Biol"},{"key":"2025010315121674500_etc3797-bib-0062","first-page":"875824","article-title":"The role of HDAC6 in cancer","volume":"2011","author":"Aldana-Masangkay","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"2025010315121674500_etc3797-bib-0063","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.4161\/15384047.2014.956632","article-title":"HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process","volume":"15","author":"Zhang","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"2025010315121674500_etc3797-bib-0064","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/pcp\/pcs004","article-title":"An epigenetic integrator: New insights into genome regulation, environmental stress responses and developmental controls by histone deacetylase 6","volume":"53","author":"Kim","year":"2012","journal-title":"Plant Cell Physiol"},{"key":"2025010315121674500_etc3797-bib-0065","doi-asserted-by":"crossref","first-page":"e0121247","DOI":"10.1371\/journal.pone.0121247","article-title":"Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway","volume":"10","author":"Bai","year":"2015","journal-title":"PLoS One"},{"key":"2025010315121674500_etc3797-bib-0066","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.fsi.2015.08.011","article-title":"Vitellogenin is an immunocompetent molecule for mother and offspring in fish","volume":"46","author":"Zhang","year":"2015","journal-title":"Fish Shellfish Immun"},{"key":"2025010315121674500_etc3797-bib-0067","doi-asserted-by":"crossref","first-page":"28369","DOI":"10.1074\/jbc.M113.465021","article-title":"Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species","volume":"288","author":"Havukainen","year":"2013","journal-title":"J Biol Chem"},{"key":"2025010315121674500_etc3797-bib-0068","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.micinf.2013.05.002","article-title":"Vitellogenins increase stress resistance of Caenorhabditis elegans after Photorhabdus luminescens infection depending on the steroid-signaling pathway","volume":"15","author":"Fischer","year":"2013","journal-title":"Microbes Infect"},{"key":"2025010315121674500_etc3797-bib-0069","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.chemosphere.2015.09.106","article-title":"Vitellogenin expression in wild cyprinid Petroleuciscus esfahani as a biomarker of endocrine disruption along the Zayandeh Roud River, Iran","volume":"144","author":"Gilannejad","year":"2016","journal-title":"Chemosphere"},{"key":"2025010315121674500_etc3797-bib-0070","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12601-014-0013-x","article-title":"Vitellogenin gene characterization and expression of Asian paddle crabs (Charybdis japonica) following endocrine disrupting chemicals","volume":"49","author":"Park","year":"2014","journal-title":"Ocean Sci J"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fetc.3797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/36\/10\/2602\/59775617\/etc3797.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/36\/10\/2602\/59775617\/etc3797.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:57:47Z","timestamp":1750121867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/36\/10\/2602\/7740348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":70,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,3,17]]},"published-print":{"date-parts":[[2017,3,17]]}},"URL":"https:\/\/doi.org\/10.1002\/etc.3797","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10,1]]},"published":{"date-parts":[[2017,3,17]]},"assertion":[{"value":"2017-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}