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We identified rapid steady-state accumulation of diphenhydramine across zebrafish embryo and larval stages. However, significantly (p\u2009&amp;lt;\u20090.05) lower accumulation was observed at 48\u2009h compared to 96\u2009h in chorionated and dechorionated embryos (0\u20134 dpf), but not in zebrafish at 7 to 11 and 14 to 18\u2009dpf. Increased uptake and toxicity of diphenhydramine was further observed in zebrafish at 7 to 11 and 14 to 18 dpf compared with 0\u20134 dpf embryos with chorion or dechorionated, which indicates that differential zebrafish sensitivity with age is associated with accumulation resulting from gill and other toxicokinetic and toxicodynamic changes during development. Environ Toxicol Chem 2018;37:1175\u20131181. \u00a9 2017 SETAC<\/jats:p><\/jats:sec>","DOI":"10.1002\/etc.4068","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T11:12:07Z","timestamp":1514113927000},"page":"1175-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Differential uptake of and sensitivity to diphenhydramine in embryonic and larval zebrafish"],"prefix":"10.1093","volume":"37","author":[{"given":"Lauren A.","family":"Kristofco","sequence":"first","affiliation":[{"name":"Department of Environmental ScienceCenter for Reservoir and Aquatic Systems ResearchBaylor University Waco Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel P.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Environmental ScienceCenter for Reservoir and Aquatic Systems ResearchBaylor University Waco Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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