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This has resulted in the emergence of landscape ecotoxicology, a subdiscipline of ecotoxicology. However, landscape ecotoxicology has yet to become common practice in risk assessment due to the underdevelopment of techniques and a lack of standardized methods. In the present study, we demonstrate how geographic information systems (GISs) can serve as a standardized platform to integrate data, assess spatial patterns of ecotoxicological data for multiple species, and assess relationships between chemical mixture exposures and effects on biota for landscape ecotoxicological risks assessment. We use data collected under the Joint Oil Sands Monitoring Program in the Athabasca Oil Sands Region in Alberta, Canada. This dataset is composed of concentrations of contaminants including metals and polycyclic aromatic compounds, and health endpoints measured in 1100 biological samples, including tree swallows, amphibians, gull and tern eggs, plants, and mammals. We present 3 examples using a GIS as a platform and geospatial analysis to: 1) integrate data and assess spatial patterns of contaminant exposure in the region, 2) assess spatial patterns of exposures to complex mixtures, and 3) examine patterns of exposures and responses across the landscape. We summarize the methods used in the present study into a workflow for ease of use. The GIS methods allow researchers to identify hot spots of contamination, use georeferenced monitoring data to derive quantitative exposure-response relationships, and assess complex exposures with more realism. Environ Toxicol Chem 2019;38:2797\u20132810. \u00a9 2019 SETAC<\/jats:p>\n               <jats:p>Abstract<\/jats:p>\n               <jats:p>Chemical exposures to biota in regions of anthropogenic disturbance can be spatially assessed to quantity how exposures and responses vary across the landscape. These patterns and relationships can be used to inform and refine future biomonitoring programs. \u2009<\/jats:p>","DOI":"10.1002\/etc.4577","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T15:34:46Z","timestamp":1566401686000},"page":"2797-2810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Use of Geographic Information Systems for Spatial Ecological Risk Assessments: An Example from the Athabasca Oil Sands Area in Canada"],"prefix":"10.1093","volume":"38","author":[{"given":"Kristin M.","family":"Eccles","sequence":"first","affiliation":[{"name":"Science and Technology Branch, Environment and Climate Change Canada, National Wildlife Research Center Ottawa Ontario Canada"},{"name":"Department of Biology University of Ottawa, Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce 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