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Although lethal effects of narcosis-inducing chemicals (NICs) have been thoroughly investigated, knowledge of sublethal effects is still very limited. We investigated the effects of 3 well-known NICs (phenanthrene, 1,3,5-trichlorobenzene, and pentachlorobenzene) on a variety of organismal endpoints (malformations, swim bladder inflation, respiration, heart rate, swimming activity, and turning angles), which can be plausibly linked to narcosis in zebrafish embryos. Baseline toxicity recorded as mortality is typically observed in similar exposure ranges in a wide variety of species including fish, corresponding to a chemical activity range between 0.01 and 0.1. In the present study, we found that sublethal effects occurred at concentrations approximately 5 times below lethal concentrations. Altered swimming activity and impaired swim bladder inflation were the most sensitive endpoints occurring at exposure levels below the generally accepted threshold for baseline toxicity for 2 out of 3 compounds. Overall, most effective exposure levels across the sublethal endpoints and compounds did fall within the range typically associated with baseline toxicity, and deviations were generally limited to a factor 10. Although there could be benefit in adding sublethal endpoints to toxicity tests, such as the fish embryo acute toxicity (FET) test, based on the present sublethal endpoints and available evidence from our and other studies, the underestimation of toxicity as a result of the sole assessment of mortality as an endpoint in an FET test may be limited for narcosis. Environ Toxicol Chem 2021;40:2802\u20132812. \u00a9 2021 SETAC<\/jats:p>","DOI":"10.1002\/etc.5170","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T20:26:01Z","timestamp":1626812761000},"page":"2802-2812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sublethal Effect Concentrations for Nonpolar Narcosis in the Zebrafish Embryo"],"prefix":"10.1093","volume":"40","author":[{"given":"Riccardo","family":"Massei","sequence":"first","affiliation":[{"name":"Zebrafishlab, Veterinary, Department of Veterinary Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-8114","authenticated-orcid":false,"given":"Dries","family":"Knapen","sequence":"additional","affiliation":[{"name":"Zebrafishlab, Veterinary, Department of Veterinary Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Covaci","sequence":"additional","affiliation":[{"name":"Toxicological Centre, Department of Pharmaceutical Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Blust","sequence":"additional","affiliation":[{"name":"Systemic Physiological and Ecotoxicological Research, Department of Biology University of Antwerp, Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering Technical University of Denmark, Kgs. 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