{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:52:32Z","timestamp":1777791152806,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002257","name":"Nickel Producers Environmental Research Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011669","name":"International Zinc Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002257","name":"Nickel Producers Environmental Research Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011669","name":"International Zinc Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We studied biotic ligand model (BLM) predictions of the toxicity of nickel (Ni) and zinc (Zn) in natural waters from Illinois and Minnesota, USA, which had combinations of pH, hardness, and dissolved organic carbon (DOC) more extreme than 99.7% of waters in a nationwide database. We conducted 7-day chronic tests with Ceriodaphnia dubia and 96-hour acute and 14-day chronic tests with Neocloeon triangulifer and estimated median lethal concentrations and 20% effect concentrations for both species. Toxicity of Ni and Zn to both species differed among test waters by factors from 8 (Zn tests with C. dubia) to 35 (Zn tests with N. triangulifer). For both species and metals, tests with Minnesota waters (low pH and hardness, high DOC) showed lower toxicity than Illinois waters (high pH and high hardness, low DOC). Recalibration of the Ni BLM to be more responsive to pH-related changes improved predictions of Ni toxicity, especially for C. dubia. For the Zn BLM, we compared several input data scenarios, which generally had minor effects on model performance scores (MPS). A scenario that included inputs of modeled dissolved inorganic carbon and measured Al and Fe(III) produced the highest MPS values for tests with both C. dubia and N. triangulifer. Overall, the BLM framework successfully modeled variation in toxicity for both Zn and Ni across wide ranges of water chemistry in tests with both standard and novel test organisms. Environ Toxicol Chem 2021;40:3049\u20133062. \u00a9 2021 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.<\/jats:p>","DOI":"10.1002\/etc.5178","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T20:35:46Z","timestamp":1627072546000},"page":"3049-3062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Modeling the Bioavailability of Nickel and Zinc to <i>Ceriodaphnia dubia<\/i> and <i>Neocloeon triangulifer<\/i> in Toxicity Tests with Natural Waters"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9464-2244","authenticated-orcid":false,"given":"John M.","family":"Besser","sequence":"first","affiliation":[{"name":"US Geological Survey Columbia Environmental Research Center Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris D.","family":"Ivey","sequence":"additional","affiliation":[{"name":"US Geological Survey Columbia Environmental Research Center Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery A.","family":"Steevens","sequence":"additional","affiliation":[{"name":"US Geological Survey Columbia Environmental Research Center Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-4584","authenticated-orcid":false,"given":"Danielle","family":"Cleveland","sequence":"additional","affiliation":[{"name":"US Geological Survey Columbia Environmental Research Center Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-0193","authenticated-orcid":false,"given":"David","family":"Soucek","sequence":"additional","affiliation":[{"name":"Illinois Natural History Survey Champaign-Urbana Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Illinois Natural History Survey Champaign-Urbana Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Van Genderen","sequence":"additional","affiliation":[{"name":"International Zinc Association Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C.","family":"Ryan","sequence":"additional","affiliation":[{"name":"International Zinc Association Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris E.","family":"Schlekat","sequence":"additional","affiliation":[{"name":"Nickel Producers Environmental Research Association Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Garman","sequence":"additional","affiliation":[{"name":"Nickel Producers Environmental Research Association Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-2774","authenticated-orcid":false,"given":"Ellie","family":"Middleton","sequence":"additional","affiliation":[{"name":"Nickel Producers Environmental Research Association Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Santore","sequence":"additional","affiliation":[{"name":"Windward Environmental Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2025010313401503300_etc5178-bib-0001","volume-title":"Standard methods for the examination of water and wastewater","author":"American Public Health Association","year":"2005","edition":"21st ed."},{"key":"2025010313401503300_etc5178-bib-0002","author":"ASTM International","year":"2015"},{"key":"2025010313401503300_etc5178-bib-0003","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1016\/j.scitotenv.2011.06.061","article-title":"The sensitivity of aquatic insects to divalent metals: A comparative analysis of laboratory and field data","volume":"409","author":"Brix","year":"2011","journal-title":"Science of the Total Environment"},{"key":"2025010313401503300_etc5178-bib-0004","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/etc.4570","article-title":"Development of empirical bioavailability models for metals","volume":"39","author":"Brix","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0005","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/etc.1810","article-title":"Application of US EPA guidelines in a bioavailability-based assessment of ambient water quality criteria for zinc in freshwater","volume":"31","author":"DeForest","year":"2012","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0006","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aquatox.2007.03.025","article-title":"Comparison of nickel toxicity to cladocerans in soft versus hard surface waters","volume":"84","author":"Deleebeeck","year":"2007","journal-title":"Aquatic Toxicology"},{"key":"2025010313401503300_etc5178-bib-0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ecoenv.2007.05.002","article-title":"The acute toxicity of nickel to Daphnia magna: Predictive capacity of bioavailability models in artificial and natural waters","volume":"70","author":"Deleebeeck","year":"2008","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"6","key":"2025010313401503300_etc5178-bib-0008","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.scitotenv.2008.11.052","article-title":"Effects of Mg2+ and H+ on the toxicity of Ni2+ to the unicellular green alga Pseudokirchneriella subcapitata: Model development and validation with surface waters","volume":"407","author":"Deleebeeck","year":"2009","journal-title":"Science of the Total Environment"},{"key":"2025010313401503300_etc5178-bib-0009","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/etc.5620201034","article-title":"Biotic ligand model of the acute toxicity of metals. 1. Technical basis","volume":"20","author":"Di Toro","year":"2001","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0010","author":"Erickson","year":"2015"},{"key":"2025010313401503300_etc5178-bib-0011","author":"European Commission","year":"2010"},{"key":"2025010313401503300_etc5178-bib-0012","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/etc.4563","article-title":"Validation of bioavailability-based toxicity models for metals","volume":"39","author":"Garman","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0013","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/es60130a004","article-title":"Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays","volume":"11","author":"Hamilton","year":"1977","journal-title":"Environmental Science & Technology"},{"key":"2025010313401503300_etc5178-bib-0014","author":"Ivey","year":"2020"},{"key":"2025010313401503300_etc5178-bib-0015","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1897\/07-326.1","article-title":"Dissolved fraction of standard laboratory cladoceran food alters toxicity of waterborne silver to Ceriodaphnia dubia","volume":"27","author":"Kolts","year":"2008","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0016","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/etc.4560","article-title":"Metal bioavailability models: Current status, lessons learned, considerations for regulatory use, and the path forward","volume":"39","author":"Mebane","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0017","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/etc.3599","article-title":"Larval aquatic insect responses to cadmium and zinc in experimental streams","volume":"36","author":"Mebane","year":"2017","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0018","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/etc.4663","article-title":"Bioaccumulation and toxicity of cadmium, copper, nickel, and zinc and their mixtures to aquatic insect communities","volume":"39","author":"Mebane","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0019","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/etc.3232","article-title":"The effect of pH on chronic aquatic nickel toxicity is dependent on the pH itself: Extending the chronic nickel bioavailability models","volume":"35","author":"Nys","year":"2016","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2389.1989.tb01252.x","article-title":"The reactions of copper and zinc with calcium carbonate surfaces","volume":"40","author":"Papadopoulos","year":"1989","journal-title":"European Journal of Soil Science"},{"key":"2025010313401503300_etc5178-bib-0021","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/etc.4213","article-title":"Validation of the nickel biotic ligand model for locally relevant species in Australian freshwaters","volume":"7","author":"Peters","year":"2018","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0022","author":"Santore","year":"2019"},{"issue":"8","key":"2025010313401503300_etc5178-bib-0023","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/etc.5109","article-title":"A review of water quality factors that affect nickel bioavailability to aquatic organisms: Refinement of the biotic ligand model for nickel in acute and chronic exposures","volume":"40","author":"Santore","year":"2021","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0024","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1016\/j.scitotenv.2010.09.012","article-title":"Cross-species extrapolation of chronic nickel biotic ligand models","volume":"408","author":"Schlekat","year":"2010","journal-title":"Science of the Total Environment"},{"key":"2025010313401503300_etc5178-bib-0025","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/etc.4683","article-title":"Acute and chronic toxicity of nickel and zinc to a laboratory cultured mayfly, Neocloeon triangulifer, in aqueous but fed exposures","volume":"39","author":"Soucek","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0026","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/etc.2773","article-title":"Testing WHAM-Ftox with laboratory toxicity data for mixtures of metals (Cu, Zn, Cd, Ag, Pb)","volume":"34","author":"Tipping","year":"2015","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0028","author":"US Environmental Protection Agency","year":"2002"},{"key":"2025010313401503300_etc5178-bib-0029","author":"US Environmental Protection Agency","year":"2007"},{"key":"2025010313401503300_etc5178-bib-0032","author":"US Environmental Protection Agency","year":"2016"},{"key":"2025010313401503300_etc5178-bib-0031","author":"US Environmental Protection Agency","year":"2021"},{"key":"2025010313401503300_etc5178-bib-0033","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1002\/etc.3840","article-title":"Analyzing the capacity of the Daphnia magna and Pseudokirchneriella subcapitata bioavailability models to predict chronic zinc toxicity at high pH and low calcium concentrations and formulation of a generalized bioavailability model for D. magna","volume":"36","author":"Van Regenmortel","year":"2017","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2025010313401503300_etc5178-bib-0034","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/etc.4841","article-title":"Evaluation of acute and chronic toxicity of nickel and zinc to two sensitive freshwater benthic invertebrates using refined testing methods","volume":"39","author":"Wang","year":"2020","journal-title":"Environmental Toxicology and Chemistry"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/etc.5178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/etc.5178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/40\/11\/3049\/59784600\/etc5178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/40\/11\/3049\/59784600\/etc5178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T14:18:46Z","timestamp":1735913926000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/40\/11\/3049\/7734454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,7,23]]},"published-print":{"date-parts":[[2021,7,23]]}},"URL":"https:\/\/doi.org\/10.1002\/etc.5178","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,7,23]]},"assertion":[{"value":"2020-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}