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The long-term ecological impact on the aquatic environment is unknown. Many sources allow entry of antibiotics into the environment, including wastewater-treatment plants (WWTPs), agricultural runoff, hospital effluent, and landfill leachate. Concentrations of antibiotics in the aquatic environment vary significantly; studies have shown fluoroquinolones, tetracycline, macrolides, sulfonamides, and penicillins to reach 2900, 1500, 9700, 21 400, and 1600\u2009ng L\u20131 in wastewater effluent samples, respectively. However, concentrations are highly variable between different countries and depend on several factors including seasonal variation, prescription, and WWTP operating procedures. Likewise, the reported concentrations that cause environmental effects vary greatly between antibiotics, even within the same class; however, this predicted concentration for the antibiotics considered was frequently &amp;lt;1000\u2009ngL\u20131, indicating that when discharged into the environment along with treated effluent, these antibiotics have a potentially detrimental effect on the environment. Antibiotics are generally quite hydrophilic in nature; however, they can ionize in the aquatic environment to form charged structures, such as cations, zwitterions, and anions. Certain classes, particularly fluoroquinolones and tetracyclines, can adsorb onto solid matrices, including soils, sediment, and sludge, making it difficult to fully understand their chemical fate in the aquatic environment. The adsorption coefficient (Kd) varies between different classes of antibiotics, with tetracyclines and fluoroquinolones showing the highest Kd values. The Kd values for fluoroquinolones, tetracyclines, macrolides, and sulfonamides have been reported as 54 600, 7600, 130, and 1.37\u2009L\u2009kg\u20131, respectively. Factors such as pH of the environment, solid matrix (sediment\/soil sludge), and ionic strength can influence the Kd; therefore, several values exist in literature for the same compound. Environ Toxicol Chem 2021;40:3275\u20133298. \u00a9 2021 SETAC<\/jats:p>","DOI":"10.1002\/etc.5191","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T16:47:50Z","timestamp":1628700470000},"page":"3275-3298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":239,"title":["Chemical Fate and Partitioning Behavior of Antibiotics in the Aquatic Environment\u2014A Review"],"prefix":"10.1093","volume":"40","author":[{"given":"Jamie","family":"Harrower","sequence":"first","affiliation":[{"name":"The James Hutton Institute, Cragiebuckler Aberdeen AB15 8QH Scotland United Kingdom"},{"name":"Glasgow Caledonian University Cowcaddens Road, Glasgow G4 0BA Scotland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyra","family":"McNaughtan","sequence":"additional","affiliation":[{"name":"Glasgow Caledonian University Cowcaddens Road, Glasgow G4 0BA Scotland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hunter","sequence":"additional","affiliation":[{"name":"Glasgow Caledonian University Cowcaddens Road, Glasgow G4 0BA Scotland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Hough","sequence":"additional","affiliation":[{"name":"The James Hutton Institute, Cragiebuckler Aberdeen AB15 8QH Scotland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The James Hutton Institute, Cragiebuckler Aberdeen AB15 8QH Scotland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Helwig","sequence":"additional","affiliation":[{"name":"Glasgow Caledonian University Cowcaddens Road, Glasgow G4 0BA Scotland United 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