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We present data on hepatic residues of ARs in 741 raptorial birds found dead or brought into rehabilitation centers in British Columbia, Canada, over a 30-year period from 1988 to 2018. Exposure varied by species, by proximity to residential areas, and over time, with at least one SGAR residue detected in 74% of individuals and multiple residues in 50% of individuals. By comparison, we detected first-generation compounds in &amp;lt;5% of the raptors. Highest rates of exposure were in barred owls (Strix varia), 96%, and great horned owls (Bubo virginianus), 81%, species with diverse diets, including rats (Rattus norvegicus and Rattus rattus), and inhabiting suburban and intensive agricultural habitats. Barn owls (Tyto alba), mainly a vole (Microtus) eater, had a lower incidence of exposure of 65%. Putatively, bird-eating raptors also had a relatively high incidence of exposure, with 75% of Cooper's hawks (Accipiter cooperii) and 60% of sharp-shinned hawks (Accipiter striatus) exposed. Concentrations of SGARs varied greatly, for example, in barred owls, the geometric mean \u2211SGAR\u2009=\u20090.13, ranging from &amp;lt;0.005 to 1.81\u2009\u03bcg\/g\u2009wet weight (n\u2009=\u2009208). Barred owls had significantly higher \u2211SGAR concentrations than all other species, driven by significantly higher bromadiolone concentrations, which was predicted by the proportion of residential land within their home ranges. Preliminary indications that risk mitigation measures implemented in 2013 are having an influence on exposure include a decrease in mean concentrations of brodifacoum and difethialone in barred and great horned owls and an increase in bromodialone around that inflection point. Environ Toxicol Chem 2022;41:1903\u20131917. \u00a9 2022 Her Majesty the Queen in Right of Canada. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Reproduced with the permission of the Minister of Environment and Climate Change Canada.<\/jats:p>","DOI":"10.1002\/etc.5361","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T09:19:13Z","timestamp":1654766353000},"page":"1903-1917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Anticoagulant Rodenticide Contamination of Terrestrial Birds of Prey from Western Canada: Patterns and Trends, 1988\u20132018"],"prefix":"10.1093","volume":"41","author":[{"given":"John E.","family":"Elliott","sequence":"first","affiliation":[{"name":"Ecotoxicology and Wildlife Health Directorate Environment and Climate Change Canada Delta British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-273X","authenticated-orcid":false,"given":"Veronica","family":"Silverthorn","sequence":"additional","affiliation":[{"name":"Ecotoxicology and Wildlife Health Directorate Environment and Climate Change Canada Delta British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofi","family":"Hindmarch","sequence":"additional","affiliation":[{"name":"Ecotoxicology and Wildlife Health Directorate Environment and Climate Change Canada Delta British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandi","family":"Lee","sequence":"additional","affiliation":[{"name":"Ecotoxicology and Wildlife Health Directorate Environment and Climate Change Canada Delta British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bowes","sequence":"additional","affiliation":[{"name":"Animal Health Centre BC Ministry of Agriculture Abbotsford British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Redford","sequence":"additional","affiliation":[{"name":"Animal Health Centre BC Ministry of 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