{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:05:11Z","timestamp":1768784711508,"version":"3.49.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["No. Y2022GH10"],"award-info":[{"award-number":["No. Y2022GH10"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["WUT: 193108003"],"award-info":[{"award-number":["WUT: 193108003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2019IVA032"],"award-info":[{"award-number":["2019IVA032"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Scottish Government's Rural and Environment Science and Analytical Services Division"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 41428601"],"award-info":[{"award-number":["No. 41428601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 51878523"],"award-info":[{"award-number":["No. 51878523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 52170171"],"award-info":[{"award-number":["No. 52170171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To our knowledge, ours is the first study to investigate the annual fluxes, environmental fate, and ecological risks of five categories of antibiotics from the Wuhan section of the Yangtze River (China). All the 24 antibiotics we tested for were detected in water, with total concentrations of 17.11\u2013867.2\u2009ng\/L (mean: 63.69\u2009ng\/L), and 19 antibiotics were detected in sediment, at 0.02\u2013287.7\u2009ng\/g (mean: 16.54\u2009ng\/g). Sulfonamides, amphenicols, and macrolides were the three most prominent antibiotic classes in water, and fluoroquinolones were the most prominent in sediment. Farming activities (animal husbandry and aquaculture) are proposed as the largest contributors to antibiotic pollution in the Wuhan section of the Yangtze River according to the Unmix model, followed by municipal wastewater and mixed sources. Higher pollution levels were observed downstream (combined discharge of these sources). Monthly monitoring data (12 months) were used to estimate antibiotic annual fluxes, with 101.5 t (uncertainty: 5.6%) in the Wuhan section of the Yangtze River. Risk assessments showed that erythromycin, clarithromycin, and azithromycin posed medium and high ecological risks and were found in 9%\u201335% and 1.8%\u20133.7% of all water samples, respectively; enrofloxacin, clarithromycin, azithromycin, florfenicol, and thiamphenicol posed medium resistance risks in 1.9%\u201316.7% of waters in the Wuhan section of the Yangtze River. Our results have filled data gaps on antibiotic sources, annual fluxes, and resistance risk in the Wuhan section of the Yangtze River and demonstrated the importance of further management of antibiotic use in the studied areas. Environ Toxicol Chem 2023;42:605\u2013619. \u00a9 2022 SETAC<\/jats:p>","DOI":"10.1002\/etc.5553","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:45:31Z","timestamp":1672382731000},"page":"605-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Estimating Sources, Fluxes, and Ecological Risks of Antibiotics in the Wuhan Section of the Yangtze River, China: A Year-Long Investigation"],"prefix":"10.1093","volume":"42","author":[{"given":"Yulin","family":"Chen","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Tan","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yile","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfei","family":"Ma","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Farmland Irrigation Research Institute Chinese Academy of Agricultural Sciences Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjie","family":"Du","sequence":"additional","affiliation":[{"name":"Farmland Irrigation Research Institute Chinese Academy of Agricultural Sciences Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lie","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Water Conservancy and Civil Engineering Northeast Agricultural University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhen","family":"Ding","sequence":"additional","affiliation":[{"name":"Agro-Environmental Protection Institute Ministry of Agriculture and Rural Affairs Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebin","family":"Qi","sequence":"additional","affiliation":[{"name":"Farmland Irrigation Research Institute Chinese Academy of Agricultural Sciences Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The James Hutton Institute Aberdeen UK"},{"name":"Hubei Key Laboratory of Mineral Resources Processing and Environment, School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"2025010313380876300_etc5553-bib-0001","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environment International"},{"issue":"4","key":"2025010313380876300_etc5553-bib-0002","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.2134\/jeq2004.0261","article-title":"Surface runoff and transport of sulfonamide antibiotics and tracers on manured grassland","volume":"34","author":"Burkhardt","year":"2005","journal-title":"Journal of Environmental Quality"},{"key":"2025010313380876300_etc5553-bib-0003","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.watres.2018.02.066","article-title":"Temporal and spatial variation in pharmaceutical concentrations in an urban river system","volume":"137","author":"Burns","year":"2018","journal-title":"Water Research"},{"issue":"4\u22125","key":"2025010313380876300_etc5553-bib-0004","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/clen.200900038","article-title":"Pharmaceuticals, personal care products and endocrine disrupting agents in the environment\u2014A review","volume":"37","author":"Caliman","year":"2009","journal-title":"CLEAN\u2014Soil, Air, Water"},{"key":"2025010313380876300_etc5553-bib-0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.watres.2017.12.044","article-title":"Spatial patterns of pharmaceuticals and wastewater tracers in the Hudson River Estuary","volume":"137","author":"Cantwell","year":"2018","journal-title":"Water Research"},{"issue":"1\u20133","key":"2025010313380876300_etc5553-bib-0006","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.scitotenv.2005.06.035","article-title":"Are pharmaceuticals potent environmental pollutants? Part I: Environmental risk assessments of selected active pharmaceutical ingredients","volume":"364","author":"Carlsson","year":"2006","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0007","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.scitotenv.2017.11.054","article-title":"Characterization of antibiotics in a large-scale river system of China: Occurrence pattern, spatiotemporal distribution and environmental risks","volume":"618","author":"Chen","year":"2018","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0008","doi-asserted-by":"crossref","first-page":"148352","DOI":"10.1016\/j.scitotenv.2021.148352","article-title":"Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China","volume":"792","author":"Chen","year":"2021","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0009","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fmicb.2019.00338","article-title":"Antibiotics in the soil environment\u2014Degradation and their impact on microbial activity and diversity","volume":"10","author":"Cycon","year":"2019","journal-title":"Frontiers in Microbiology"},{"issue":"7\u22128","key":"2025010313380876300_etc5553-bib-0010","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.eiar.2004.06.003","article-title":"Non-regulated water contaminants: Emerging research","volume":"24","author":"Daughton","year":"2004","journal-title":"Environmental Impact Assessment Review"},{"key":"2025010313380876300_etc5553-bib-0011","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ecoenv.2019.03.075","article-title":"Presence and environmental risk assessment of selected antibiotics in coastal water adjacent to mariculture areas in the Bohai Sea","volume":"177","author":"Du","year":"2019","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2025010313380876300_etc5553-bib-0012","author":"European Commission","year":"2003"},{"key":"2025010313380876300_etc5553-bib-0013","first-page":"11","author":"European Commission","year":"2014"},{"key":"2025010313380876300_etc5553-bib-0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.microc.2017.02.006","article-title":"Ecological effects of antibiotics on natural ecosystems: A review","volume":"136","author":"Grenni","year":"2018","journal-title":"Microchemical Journal"},{"issue":"6","key":"2025010313380876300_etc5553-bib-0015","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.atmosenv.2008.04.046","article-title":"Receptor modeling of source apportionment of Hong Kong aerosols and the implication of urban and regional contribution","volume":"43","author":"Guo","year":"2009","journal-title":"Atmospheric Environment"},{"key":"2025010313380876300_etc5553-bib-0016","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.scitotenv.2019.03.393","article-title":"Spatial distribution, source apportionment and risk assessment of antibiotics in the surface water and sediments of the Yangtze Estuary","volume":"671","author":"Guo","year":"2019","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0017","doi-asserted-by":"crossref","first-page":"143863","DOI":"10.1016\/j.scitotenv.2020.143863","article-title":"Antibiotics in marine aquaculture farms surrounding Laizhou Bay, Bohai Sea: Distribution characteristics considering various culture modes and organism species","volume":"760","author":"Han","year":"2021","journal-title":"Science of the Total Environment"},{"issue":"2","key":"2025010313380876300_etc5553-bib-0018","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s11356-021-15363-7","article-title":"Pharmaceuticals in drinking water sources and tap water in a city in the middle reaches of the Yangtze River: Occurrence, spatiotemporal distribution, and risk assessment","volume":"29","author":"He","year":"2022","journal-title":"Environmental Science and Pollution Research"},{"issue":"1\u22122","key":"2025010313380876300_etc5553-bib-0019","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0169-7439(01)00184-8","article-title":"Multivariate receptor models\u2014Current practice and future trends","volume":"60","author":"Henry","year":"2002","journal-title":"Chemometrics and Intelligent Laboratory Systems"},{"key":"2025010313380876300_etc5553-bib-0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.chemosphere.2017.08.152","article-title":"Occurrence, distribution, ecological and resistance risks of antibiotics in surface water of finfish and shellfish aquaculture in Bangladesh","volume":"188","author":"Hossain","year":"2017","journal-title":"Chemosphere"},{"issue":"2","key":"2025010313380876300_etc5553-bib-0021","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1021\/es3030148","article-title":"Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems","volume":"47","author":"Hughes","year":"2013","journal-title":"Environmental Science & Technology"},{"issue":"3","key":"2025010313380876300_etc5553-bib-0022","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41559-016-0051","article-title":"Bioaccumulation of persistent organic pollutants in the deepest ocean fauna","volume":"1","author":"Jamieson","year":"2017","journal-title":"Nature Ecology & Evolution"},{"issue":"9","key":"2025010313380876300_etc5553-bib-0023","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tim.2014.05.005","article-title":"Fate and effects of veterinary antibiotics in soil","volume":"22","author":"Jechalke","year":"2014","journal-title":"Trends in Microbiology"},{"key":"2025010313380876300_etc5553-bib-0024","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.chemosphere.2014.04.075","article-title":"Distribution and ecological risk of antibiotics in a typical effluent-receiving river (Wangyang River) in north China","volume":"112","author":"Jiang","year":"2014","journal-title":"Chemosphere"},{"issue":"3","key":"2025010313380876300_etc5553-bib-0025","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tim.2017.09.005","article-title":"Antibiotic-resistance genes in waste water","volume":"26","author":"Karkman","year":"2018","journal-title":"Trends in Microbiology"},{"issue":"1","key":"2025010313380876300_etc5553-bib-0026","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/es060737+","article-title":"Temporal and spatial trends in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices","volume":"41","author":"Kim","year":"2007","journal-title":"Environmental Science & Technology"},{"issue":"4","key":"2025010313380876300_etc5553-bib-0027","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment\u2014A review\u2014Part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"2025010313380876300_etc5553-bib-0028","doi-asserted-by":"crossref","first-page":"104919","DOI":"10.1016\/j.envint.2019.104919","article-title":"Spatial and seasonal variations of antibiotics in river waters in the Haihe River Catchment in China and ecotoxicological risk assessment","volume":"130","author":"Lei","year":"2019","journal-title":"Environment International"},{"issue":"3","key":"2025010313380876300_etc5553-bib-0029","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/10473289.2003.10466155","article-title":"Source apportionment of phoenix PM2.5 aerosol with the Unmix receptor model","volume":"53","author":"Lewis","year":"2003","journal-title":"Journal of the Air & Waste Management Association"},{"key":"2025010313380876300_etc5553-bib-0030","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.scitotenv.2018.04.358","article-title":"Antibiotics in water and sediments of rivers and coastal area of Zhuhai City, Pearl River estuary, south China","volume":"636","author":"Li","year":"2018","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0031","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.scitotenv.2017.09.328","article-title":"A duodecennial national synthesis of antibiotics in China's major rivers and seas (2005\u20132016)","volume":"615","author":"Li","year":"2018","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0032","doi-asserted-by":"crossref","first-page":"115145","DOI":"10.1016\/j.watres.2019.115145","article-title":"Occurrence and source apportionment of novel and legacy poly\/perfluoroalkyl substances in Hai River basin in China using receptor models and isomeric fingerprints","volume":"168","author":"Li","year":"2020","journal-title":"Water Research"},{"key":"2025010313380876300_etc5553-bib-0033","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.scitotenv.2018.04.267","article-title":"Pharmaceutically active compounds in the Xiangjiang River, China: Distribution pattern, source apportionment, and risk assessment","volume":"636","author":"Lin","year":"2018","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0034","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.scitotenv.2017.02.107","article-title":"Spatial distribution and removal performance of pharmaceuticals in municipal wastewater treatment plants in China","volume":"586","author":"Liu","year":"2017","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0035","doi-asserted-by":"crossref","first-page":"116187","DOI":"10.1016\/j.watres.2020.116187","article-title":"Occurrence, spatiotemporal variation, and ecological risk of antibiotics in the water of the semi-enclosed urbanized Jiaozhou Bay in eastern China","volume":"184","author":"Lu","year":"2020","journal-title":"Water Research"},{"issue":"Pt B","key":"2025010313380876300_etc5553-bib-0036","doi-asserted-by":"crossref","first-page":"127487","DOI":"10.1016\/j.jhazmat.2021.127487","article-title":"Profiling of the spatiotemporal distribution, risks, and prioritization of antibiotics in the waters of Laizhou Bay, northern China","volume":"424","author":"Lu","year":"2022","journal-title":"Journal of Hazardous Materials"},{"issue":"5","key":"2025010313380876300_etc5553-bib-0037","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/es104009s","article-title":"Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China","volume":"45","author":"Luo","year":"2011","journal-title":"Environmental Science & Technology"},{"key":"2025010313380876300_etc5553-bib-0038","doi-asserted-by":"crossref","first-page":"115147","DOI":"10.1016\/j.envpol.2020.115147","article-title":"Antibiotics in soil and water in China\u2014A systematic review and source analysis","volume":"266","author":"Lyu","year":"2020","journal-title":"Environmental Pollution"},{"key":"2025010313380876300_etc5553-bib-0039","author":"Ministry of Agriculture, People's Republic of China","year":"2015"},{"key":"2025010313380876300_etc5553-bib-0040","author":"Ministry of Agriculture, People's Republic of China","year":"2017"},{"key":"2025010313380876300_etc5553-bib-0041","author":"Ministry of Agriculture and Rural Affaiars, People's Republic of China","year":"2019"},{"key":"2025010313380876300_etc5553-bib-0042","author":"Ministry of Ecology and Environment, People's Republic of China","year":"2020"},{"issue":"13","key":"2025010313380876300_etc5553-bib-0043","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1021\/acs.est.9b01131","article-title":"Insights into the fate and removal of antibiotics in engineered biological treatment systems: A critical review","volume":"53","author":"Oberoi","year":"2019","journal-title":"Environmental Science & Technology"},{"issue":"11","key":"2025010313380876300_etc5553-bib-0044","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1007\/s11356-014-2814-y","article-title":"Estimates of pesticide concentrations and fluxes in two rivers of an extensive French multi-agricultural watershed: Application of the passive sampling strategy","volume":"22","author":"Poulier","year":"2015","journal-title":"Environmental Science and Pollution Research"},{"issue":"3","key":"2025010313380876300_etc5553-bib-0045","doi-asserted-by":"crossref","first-page":"eaau9124","DOI":"10.1126\/sciadv.aau9124","article-title":"Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence","volume":"5","author":"Prnnen","year":"2019","journal-title":"Science Advances"},{"issue":"1","key":"2025010313380876300_etc5553-bib-0046","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1038\/s41598-020-78849-3","article-title":"Global trends in antimicrobial use in aquaculture","volume":"10","author":"Schar","year":"2020","journal-title":"Scientific Reports"},{"issue":"1","key":"2025010313380876300_etc5553-bib-0047","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.marpolbul.2014.04.034","article-title":"Occurrence and distribution of antibiotics in the surface sediments of the Yangtze Estuary and nearby coastal areas","volume":"83","author":"Shi","year":"2014","journal-title":"Marine Pollution Bulletin"},{"issue":"12","key":"2025010313380876300_etc5553-bib-0048","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/antibiotics9120918","article-title":"Global trends in antimicrobial use in food animals from 2017 to 2030","volume":"9","author":"Tiseo","year":"2020","journal-title":"Antibiotics (USSR)"},{"key":"2025010313380876300_etc5553-bib-0049","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.watres.2017.12.029","article-title":"Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions\u2014A review","volume":"133","author":"Tran","year":"2018","journal-title":"Water Research"},{"issue":"6358","key":"2025010313380876300_etc5553-bib-0050","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aao1495","article-title":"Reducing antimicrobial use in food animals","volume":"357","author":"Van Boeckel","year":"2017","journal-title":"Science"},{"key":"2025010313380876300_etc5553-bib-0051","doi-asserted-by":"crossref","first-page":"122110","DOI":"10.1016\/j.jhazmat.2020.122110","article-title":"Occurrence, distribution, and source track of antibiotics and antibiotic resistance genes in the main rivers of Chongqing city, Southwest China","volume":"389","author":"Wang","year":"2020","journal-title":"Journal of Hazardous Materials"},{"key":"2025010313380876300_etc5553-bib-0052","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.scitotenv.2017.08.009","article-title":"Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China","volume":"609","author":"Wang","year":"2017","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0053","doi-asserted-by":"crossref","first-page":"150439","DOI":"10.1016\/j.scitotenv.2021.150439","article-title":"Occurrence, source apportionment and risk assessment of antibiotics in water and sediment from the subtropical Beibu Gulf, South China","volume":"806","author":"Wu","year":"2022","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0054","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.scitotenv.2013.10.022","article-title":"Historical trends of concentrations, source contributions and toxicities for PAHs in dated sediment cores from five lakes in western China","volume":"470","author":"Xu","year":"2014","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0055","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jhazmat.2013.06.001","article-title":"Source apportionment of perfluorinated compounds (PFCs) in sediments: Using three multivariate factor analysis receptor models","volume":"260","author":"Xu","year":"2013","journal-title":"Journal of Hazardous Materials"},{"key":"2025010313380876300_etc5553-bib-0056","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.envpol.2013.08.004","article-title":"Antibiotics in riverine runoff of the Pearl River Delta and Pearl River Estuary, China: Concentrations, mass loading and ecological risks","volume":"182","author":"Xu","year":"2013","journal-title":"Environmental Pollution"},{"key":"2025010313380876300_etc5553-bib-0057","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envpol.2012.12.008","article-title":"Antibiotics in the surface water of the Yangtze Estuary: Occurrence, distribution and risk assessment","volume":"175","author":"Yan","year":"2013","journal-title":"Environmental Pollution"},{"key":"2025010313380876300_etc5553-bib-0058","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.envpol.2017.10.032","article-title":"Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study","volume":"236","author":"Yao","year":"2018","journal-title":"Environmental Pollution"},{"key":"2025010313380876300_etc5553-bib-0059","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ecoenv.2016.10.006","article-title":"Occurrence and risk assessment of antibiotics in surface water and groundwater from different depths of aquifers: A case study at Jianghan Plain, central China","volume":"135","author":"Yao","year":"2017","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2025010313380876300_etc5553-bib-0060","doi-asserted-by":"crossref","first-page":"113365","DOI":"10.1016\/j.envpol.2019.113365","article-title":"Occurrence of antibiotics and antibiotic resistance genes and their correlations in lower Yangtze River, China","volume":"257","author":"Zhang","year":"2020","journal-title":"Environmental Pollution"},{"issue":"11","key":"2025010313380876300_etc5553-bib-0061","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: Source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environmental Science & Technology"},{"issue":"5","key":"2025010313380876300_etc5553-bib-0062","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s10653-017-0002-y","article-title":"Risk estimation and annual fluxes of emerging contaminants from a Scottish priority catchment to the estuary and North Sea","volume":"40","author":"Zhang","year":"2018","journal-title":"Environmental Geochemistry and Health"},{"key":"2025010313380876300_etc5553-bib-0063","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.scitotenv.2016.06.219","article-title":"Evaluation of spot and passive sampling for monitoring, flux estimation and risk assessment of pesticides within the constraints of a typical regulatory monitoring scheme","volume":"569\u2212570","author":"Zhang","year":"2016","journal-title":"Science of the Total Environment"},{"key":"2025010313380876300_etc5553-bib-0064","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.marenvres.2012.03.007","article-title":"Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities","volume":"78","author":"Zheng","year":"2012","journal-title":"Marine Environmental Research"},{"key":"2025010313380876300_etc5553-bib-0065","doi-asserted-by":"crossref","first-page":"115854","DOI":"10.1016\/j.envpol.2020.115854","article-title":"Antibiotics control in aquaculture requires more than antibiotic-free feeds: A tilapia farming case","volume":"268","author":"Zhou","year":"2021","journal-title":"Environmental Pollution"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/etc.5553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/etc.5553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/42\/3\/605\/59767918\/etc5553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/42\/3\/605\/59767918\/etc5553.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T13:45:50Z","timestamp":1735911950000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/42\/3\/605\/7729516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":65,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,12,29]]},"published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/etc.5553","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}