{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:42:26Z","timestamp":1792852946289,"version":"4.5.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed. Environ Toxicol Chem 2024;43:637\u2013652. \u00a9 2022 SETAC<\/jats:p>","DOI":"10.1002\/etc.5555","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:47:31Z","timestamp":1672382851000},"page":"637-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment"],"prefix":"10.1093","volume":"43","author":[{"given":"C\u00e9lia M.","family":"Manaia","sequence":"first","affiliation":[{"name":"Universidade Cat\u00f3lica Portuguesa, CBQF - Centro de Biotecnologia e Qu\u00edmica Fina \u2013 Laborat\u00f3rio Associado, Escola Superior de Biotecnologia Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana S.","family":"Aga","sequence":"additional","affiliation":[{"name":"Chemistry Department, University at Buffalo The State University of New York Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Cytryn","sequence":"additional","affiliation":[{"name":"Institute of Soil, Water and Environmental Sciences, Volcani Institute Agricultural Research Organization Rishon-Lezion Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Gaze","sequence":"additional","affiliation":[{"name":"European Centre for Environment and Human Health University of Exeter Medical School, Penryn Campus Cornwall UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Graham","sequence":"additional","affiliation":[{"name":"School of Engineering Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Guo","sequence":"additional","affiliation":[{"name":"Australian Centre for Water and Environmental Biotechnology The University of Queensland St. Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F. 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